Trends and overall survival after combined liver resection and thermal ablation of colorectal liver metastases: a nationwide population-based propensity score-matched study.

Autor:	de Graaff MR; Dutch Institute for Clinical Auditing, Scientific Bureau, Leiden, the Netherlands; Department of Surgery, University Medical Centre Groningen, Groningen, the Netherlands. Electronic address: m.r.de.graaff@umcg.nl., Klaase JM; Department of Surgery, University Medical Centre Groningen, Groningen, the Netherlands., den Dulk M; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands., Coolsen MME; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands., Kuhlmann KFD; Department of Surgery, Antoni van Leeuwenhoek - Dutch Cancer Institute, Amsterdam, the Netherlands., Verhoef C; Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Hartgrink HH; Department of Surgery, Leiden University Medical Centre, Leiden, the Netherlands., Derksen WJM; Department of Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands; Department of Surgery, St Antonius Hospital, Nieuwegein, the Netherlands., van den Boezem P; Department of Surgery, Radboud Medical Centre, Nijmegen, the Netherlands., Rijken AM; Department of Surgery, Amphia Medical Centre, Breda, the Netherlands., Gobardhan P; Department of Surgery, Amphia Medical Centre, Breda, the Netherlands., Liem MSL; Department of Surgery, Medical Spectrum Twente, Enschede, the Netherlands., Leclercq WKG; Department of Surgery, Máxima Medical Centre, Veldhoven, the Netherlands., Marsman HA; Department of Surgery, OLVG, Amsterdam, the Netherlands., van Duijvendijk P; Department of Surgery, Gelre Ziekenhuizen, Apeldoorn and Zutphen, the Netherlands; Department of Surgery, Isala, Zwolle, the Netherlands., Bosscha K; Department of Surgery, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands., Elfrink AKE; Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Manusama ER; Department of Surgery, Medical Centre Leeuwarden, Leeuwarden, the Netherlands., Belt EJT; Department of Surgery, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Doornebosch PG; Department of Surgery, Ijsselland Hospital, Capelle aan de Ijssel, the Netherlands., Oosterling SJ; Department of Surgery, Spaarne Gasthuis, Hoofddorp, the Netherlands., Ruiter SJS; Department of Surgery, University Medical Centre Groningen, Groningen, the Netherlands., Grünhagen DJ; Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Burgmans M; Department of Surgery, Leiden University Medical Centre, Leiden, the Netherlands., Meijerink M; Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Kok NFM; Department of Surgery, Antoni van Leeuwenhoek - Dutch Cancer Institute, Amsterdam, the Netherlands., Swijnenburg RJ; Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2024 Jan; Vol. 26 (1), pp. 34-43. Date of Electronic Publication: 2023 Sep 17.
DOI:	10.1016/j.hpb.2023.09.012
Abstrakt:	Background: In colorectal liver metastases (CRLM) patients, combination of liver resection and ablation permit a more parenchymal-sparing approach. This study assessed trends in use of combined resection and ablation, outcomes, and overall survival (OS). Methods: This population-based study included all CRLM patients who underwent liver resection between 2014 and 2022. To assess OS, data was linked to two databases containing date of death for patients treated between 2014 and 2018. Hospital variation in the use of combined minor liver resection and ablation versus major liver resection alone in patients with 2-3 CRLM and ≤3 cm was assessed. Propensity score matching (PSM) was applied to evaluate outcomes. Results: This study included 3593 patients, of whom 1336 (37.2%) underwent combined resection and ablation. Combined resection increased from 31.7% in 2014 to 47.9% in 2022. Significant hospital variation (range 5.9-53.8%) was observed in the use of combined minor liver resection and ablation. PSM resulted in 1005 patients in each group. Major morbidity was not different (11.6% vs. 5%, P = 1.00). Liver failure occurred less often after combined resection and ablation (1.9% vs. 0.6%, P = 0.017). Five-year OS rates were not different (39.3% vs. 33.9%, P = 0.145). Conclusion: Combined resection and ablation should be available and considered as an alternative to resection alone in any patient with multiple metastases. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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