| Autor: |
Kaur M; Department of Biophysics, Panjab University, Chandigarh, India., Sharma A; Department of Biophysics, Panjab University, Chandigarh, India.; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India., Kaur H; Department of Biophysics, Panjab University, Chandigarh, India., Singh M; Department of Biophysics, Panjab University, Chandigarh, India., Devi B; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, UP, India., Naresh Raj AR; D.G. Vaishnav College, Chennai., Sood V; Department of Biochemistry, Jamia Hamdard, New Delhi, India., Pandey A; Department of Chemistry, Panjab University, Chandigarh, India., Gartia J; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha, India., Kumar R; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi, UP, India., Suresh Babu AR; Department of Chemistry, Anna university, CEG, Guindy Campus, Chennai, India., Singh G; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India., Barnwal RP; Department of Biophysics, Panjab University, Chandigarh, India. |
| Abstrakt: |
Monkeypox virus (MPXV) is an orthopoxvirus which causes zoonotic infection in humans. Even though sporadic cases of this infection are limited to the African continent, but if the infection continues to increase unabated, it can be a cause of serious concern for the human populace. Smallpox vaccination has been in use against monkeypox infection but it only provides mild protection. In the current study, we have screened novel small molecules (estrone fused heterocycles (EH1-EH7)) exhibiting good binding with monkeypox virus protein and related proteins from Poxviridae family of viruses via computational approaches. EH1-7 series of small molecules selected for the work have been synthesized via cycloaddition methodology. Docking and Molecular Dynamics (MD) results highlight EH4 compound to have strong binding affinity towards monkeypox and other related viral proteins selected for the study. Thus, computational outcomes suggest EH4 as a good candidate against monkeypox. Currently, no antiviral medication has been approved against monkeypox and the treatment is only via therapeutics available for smallpox and related conditions that may be helpful against monkeypox. Our study is thus an attempt to screen novel compounds against monkeypox infection, which would, in turn, facilitate development of novel therapeutics against Poxviridae family. HIGHLIGHTSMonkeypox infection is a public health emergency and necessitates immediate drug discovery.Molecular docking study to screen estrone-fused heterocycles compounds against Monkeypox and other orthopoxviruses.Molecular dynamics simulations revealed interaction/high binding affinities among EH4 heterocyclic compound and profilin-like protein from the monkeypox virus.Estrone-fused heterocycles compounds are promising anti-viral agents as per our in silico analysis.Our study provides evidence for investigating estrone-fused heterocycles compounds for further pharmacological interventions.Communicated by Ramaswamy H. Sarma. |
