Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

Autor: Shah IA; Department of Electronic Engineering, Hanyang University, Seoul, 04763, Republic of Korea., Seol HY; Department of Internal Medicine, School of Medicine, Pusan National University, Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Republic of Korea., Cho Y; Department of Electronic Engineering, Hanyang University, Seoul, 04763, Republic of Korea., Ji W; Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Seo J; Department of R&D Center, Tau Medical Inc, Busan, Republic of Korea., Lee C; Department of R&D Center, Tau Medical Inc, Busan, Republic of Korea., Chon MK; Department of Cardiology, School of Medicine & Cardiovascular center, Pusan National University & Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Shin D; Department of Pathology, School of Medicine, Pusan National University & Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Kim JH; Department of R&D Center, Tau Medical Inc, Busan, Republic of Korea., Choo KS; Department of Radiology, School of Medicine & Medical Research Institute, Pusan National University & Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Park J; Major of Human Bioconvergence, College of Information Technology and Convergence, Pukyong National University, Busan, Republic of Korea., Kim J; Department of Physiology, University of Toronto, Toronto, Canada., Yoo H; Department of Electronic Engineering, Hanyang University, Seoul, 04763, Republic of Korea. hsyoo@hanyang.ac.kr., Kim JH; Department of Cardiology, School of Medicine & Cardiovascular center, Pusan National University & Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. junehongk@gmail.com.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2023 Sep 29; Vol. 3 (1), pp. 129. Date of Electronic Publication: 2023 Sep 29.
DOI: 10.1038/s43856-023-00362-1
Abstrakt: Background: Radiofrequency ablation (RFA) is one of the treatment options for lung nodules. However, the need for exact delivery of the rigid metal electrode into the center of the target mass often leads to complications or suboptimal results. To overcome these limitations, a concept of conforming electrodes using a flexible material has been tested in this study.
Methods: A bronchoscopy-guided RFA (CAROL) under a temperature-controlled mode was tested in in-vivo and ex-vivo porcine lungs. Gallium-based liquid metal was used for turning the bronchial tree into temporary RF electrodes. A customized bronchoscopy-guided balloon-tipped guiding catheter (CAROL catheter) was used to make the procedure feasible under fluoroscopy imaging guidance. The computer simulation was also performed to gain further insight into the ablation results. Safety was also assessed including the liquid metal remaining in the body.
Results: The bronchial electrode injected from the CAROL catheter was able to turn the target site bronchial air pipe into a temporally multi-tined RF electrode. The mean volume of Gallium for each effective CAROL was 0.46 ± 0.47 ml. The ablation results showed highly efficacious and consistent results, especially in the peripheral lung. Most bronchial electrodes were also retrieved by either bronchoscopic suction immediately after the procedure or by natural expectoration thereafter. The liquid metal used in these experiments did not have any significant safety issues. Computer simulation also supports these results.
Conclusion: The CAROL ablation was very effective and safe in porcine lungs showing encouraging potential to overcome the conventional approaches.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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