Succimer chelation does not produce lasting reductions of blood lead levels in a rodent model of retained lead fragments.

Autor: Twardy SM; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA., Hanson SM; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA., Jursa T; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA., Gaitens JM; Division of Occupational and Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Kalinich JM; Division of Occupational and Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., McDiarmid MA; Division of Occupational and Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Smith DR; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. Electronic address: drsmith@ucsc.edu.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2023 Nov; Vol. 104, pp. 104283. Date of Electronic Publication: 2023 Sep 27.
DOI: 10.1016/j.etap.2023.104283
Abstrakt: Retained lead fragments from nonfatal firearm injuries pose a risk of lead poisoning. While chelation is well-established as a lead poisoning treatment, it remains unclear whether chelation mobilizes lead from embedded lead fragments. Here, we tested whether 1) DMSA/succimer or CaNa 2 EDTA increases mobilization of lead from fragments in vitro, and 2) succimer is efficacious in chelating fragment lead in vivo, using stable lead isotope tracer methods in a rodent model of embedded fragments. DMSA was > 10-times more effective than CaNa 2 EDTA in mobilizing fragment lead in vitro. In the rodent model, succimer chelation on day 1 produced the greatest blood lead reductions, and fragment lead was not mobilized into blood. However, with continued chelation and over 3-weeks post-chelation, blood lead levels rebounded with mobilization of lead from the fragments. These findings suggest prolonged chelation will increase fragment lead mobilization post-chelation, supporting the need for long-term surveillance in patients with retained fragments.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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