Characterization of urban sources of antibiotics and antibiotic-resistance genes in a Dutch sewer catchment.

Autor: Duarte DJ; Radboud University Nijmegen, Radboud Institute for Biological and Environmental Sciences, Department of Environmental Science, 6500 GL Nijmegen, Netherlands., Zillien C; Radboud University Nijmegen, Radboud Institute for Biological and Environmental Sciences, Department of Environmental Science, 6500 GL Nijmegen, Netherlands. Electronic address: caterina.zillien@ru.nl., Kox M; Deltares, Subsurface and Groundwater Systems, Daltonlaan 600, 3584 KB Utrecht, the Netherlands., Oldenkamp R; Department of Global Health-Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Paasheuvelweg 25, 1105 BP Amsterdam, the Netherlands., van der Zaan B; Deltares, Subsurface and Groundwater Systems, Daltonlaan 600, 3584 KB Utrecht, the Netherlands., Roex E; National Institute for Public Health and the Environment (RIVM), Centre for Zoonoses and Environmental Microbiology, 3721 MA Bilthoven, the Netherlands., Ragas AMJ; Radboud University Nijmegen, Radboud Institute for Biological and Environmental Sciences, Department of Environmental Science, 6500 GL Nijmegen, Netherlands.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2023 Dec 20; Vol. 905, pp. 167439. Date of Electronic Publication: 2023 Sep 27.
DOI: 10.1016/j.scitotenv.2023.167439
Abstrakt: A one year study was conducted in the city of Nijmegen, The Netherlands, to characterize various urban sources of antibiotics and antibiotic resistant genes (ARGs) in wastewater within a single sewer catchment. Prevalence of ermB, tet(W), sul1, sul2, intl1, and 16S rRNA gene was determined at 10 locations within the city. Sampling locations included a nursing home, a student residence, a hospital and an industrial area, among others. Wastewater concentrations of 23 antibiotics were measured using passive sampling. Additionally, excreted loads of 22 antibiotics were estimated based on ambulatory prescription and clinical usage data. Genes sul1 and intl1 were most abundant across most locations. Ciprofloxacin and amoxicillin together contributed over 92 % of the total estimated antibiotic selective pressure at all sampling points. The present study highlights the prominent role that hospitals can have in the prevalence and proliferation of ARGs in urban wastewater. Furthermore, results suggest that even short-term changes in the therapeutic regimen prescribed in hospitals may translate into shifting ARG abundance patterns in hospital wastewater. The methods applied present an opportunity to identify emission hotspots and prioritize intervention options to limit ARG spread from urban wastewater to the environment.
Competing Interests: Declaration of competing interest The authors declare no known conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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