Design rules for reciprocal coupling in chemically fueled assembly.
| Autor: | Chen X; Department of Chemistry, School of Natural Sciences, Technical University of Munich Lichtenbergstrasse 4 85748 Garching bei München Germany job.boekhoven@tum.de., Kriebisch BAK; Department of Chemistry, School of Natural Sciences, Technical University of Munich Lichtenbergstrasse 4 85748 Garching bei München Germany job.boekhoven@tum.de., Bergmann AM; Department of Chemistry, School of Natural Sciences, Technical University of Munich Lichtenbergstrasse 4 85748 Garching bei München Germany job.boekhoven@tum.de., Boekhoven J; Department of Chemistry, School of Natural Sciences, Technical University of Munich Lichtenbergstrasse 4 85748 Garching bei München Germany job.boekhoven@tum.de. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2023 Aug 22; Vol. 14 (37), pp. 10176-10183. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023). |
| DOI: | 10.1039/d3sc02062b |
| Abstrakt: | Biology regulates the function and assembly of proteins through non-equilibrium reaction cycles. Reciprocally, the assembly of proteins can influence the reaction rates of these cycles. Such reciprocal coupling between assembly and reaction cycle is a prerequisite for behavior like dynamic instabilities, treadmilling, pattern formation, and oscillations between morphologies. While assemblies regulated by chemical reaction cycles gained traction, the concept of reciprocal coupling is under-explored. In this work, we provide two molecular design strategies to tweak the degree of reciprocal coupling between the assembly and reaction cycle. The strategies involve spacing the chemically active site away from the assembly or burying it into the assembly. We envision that design strategies facilitate the creation of reciprocally coupled and, by extension, dynamic supramolecular materials in the future. Competing Interests: The authors declare no competing financial interest. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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