Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis.
| Autor: | Ulloque-Badaracco JR; Facultad De Ciencias De La Salud, Universidad Peruana De Ciencias Aplicadas, Lima, Peru., Hernandez-Bustamante EA; Sociedad Científica De Estudiantes De Medicina De La Universidad Nacional De Trujillo, Trujillo, Peru.; Grupo Peruano De Investigación Epidemiológica, Unidad Para La Generación y Síntesis De Evidencias En Salud, Universidad San Ignacio De Loyola, Lima, Peru., Alarcon-Braga EA; Facultad De Ciencias De La Salud, Universidad Peruana De Ciencias Aplicadas, Lima, Peru., Al-Kassab-Córdova A; Centro de Excelencia en Investigaciones Económicas y Sociales en Salud, Universidad San Ignacio de Loyola, Lima, Peru., Cabrera-Guzmán JC; Facultad De Ciencias De La Salud, Universidad Peruana De Ciencias Aplicadas, Lima, Peru., Herrera-Añazco P; Universidad Privada Del Norte, Trujillo, Peru.; Red Peruana De Salud Colectiva, Lima, Peru., Benites-Zapata VA; Unidad De Investigación Para La Generación y Síntesis De Evidencias En Salud, Vicerrectorado De Investigación, Universidad San Ignacio De Loyola, Lima, Peru. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Sep 13; Vol. 14, pp. 1221259. Date of Electronic Publication: 2023 Sep 13 (Print Publication: 2023). |
| DOI: | 10.3389/fendo.2023.1221259 |
| Abstrakt: | Background & Aims: Metabolic syndrome (MetS) is associated with life-threatening conditions. Several studies have reported an association of vitamin B12, folic acid, or homocysteine (Hcy) levels with MetS. This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and Hcy levels with MetS. Methods: PubMed, Scopus, Embase, Ovid/Medline, and Web of Science were searched up to February 13, 2023. Cross-sectional, case-control, or cohort studies were included. A random-effects model was performed using the DerSimonian and Laird method to estimate the between-study variance. Effect measures were expressed as odds ratios (OR) with their corresponding 95% confidence intervals (95% CI). Between-study heterogeneity was evaluated using Cochran's Q test and the I 2 statistic. Results: Sixty-six articles (n = 87,988 patients) were included. Higher vitamin B12 levels were inversely associated with MetS (OR = 0.87; 95% CI: 0.81-0.93; p < 0.01; I 2 = 90%). Higher Hcy levels were associated with MetS (OR = 1.19; 95% CI: 1.14-1.24; p < 0.01; I 2 = 90%). Folate levels were not associated with MetS (OR = 0.83; 95% CI: 0.66-1.03; p = 0.09; I 2 = 90%). Conclusion: Higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were associated with MetS. Studies assessing the pathways underlying this association are required. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Ulloque-Badaracco, Hernandez-Bustamante, Alarcon-Braga, Al-kassab-Córdova, Cabrera-Guzmán, Herrera-Añazco and Benites-Zapata.) |
| Databáze: | MEDLINE |
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