Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report.

Autor: Bontempo D; School of Medicine, The University of Western Australia, Nedlands, Australia., Frydrych AM; UWA Dental School, The University of Western Australia, Nedlands, Australia., Kujan O; UWA Dental School, The University of Western Australia, Nedlands, Australia., Gebauer D; Department of Oral and Maxillofacial Surgery, Royal Perth Hospital, Perth, Australia.; Department of Human Sciences, Oral Health and Equity, University of Western Australia, Perth, Australia., Fallon M; Perth Radiological Clinic, Subiaco, Australia., Panegyres PK; School of Medicine, The University of Western Australia, Nedlands, Australia.; Neurodegenerative Disorders Research Pty Ltd, West Perth, Australia.
Jazyk: angličtina
Zdroj: Oxford medical case reports [Oxf Med Case Reports] 2023 Sep 25; Vol. 2023 (9), pp. omad100. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI: 10.1093/omcr/omad100
Abstrakt: We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral mucosal involvement. A 35-year-old African Zambian man presented with headache and bleeding swollen gingiva. He was myeloperoxidase (MPO) antibody positive with cytoplasmic staining. His MRI showed stable small callosal, periventricular and subcortical white matter non-enhancing lesions, without change over 15 months-compatible with vasculitis. His gingival biopsy was consistent with vasculitis. His headache and oral lesions responded to oral corticosteroids and intravenous immunoglobulin which have induced clinical remission. Our patient expands the clinical syndrome of ANCA+ MPO+ C-type vasculitis of the central nervous system with headaches complicating cerebral vasculitis and oral mucosal involvement.
Competing Interests: There are no conflicts of interest to report.
(© The Author(s) 2023. Published by Oxford University Press.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje