The Effect of Semi-Synthetic and High-Fat High-Carbohydrate Diets Containing Cholesterol on Lipid and Cholesterol Metabolism in Male Wistar Rats.

Autor: Biryulina NA; Federal Research Center of Nutrition and Biotechnology, Moscow, Russia. biryulina_nadezhda@mail.ru., Sidorova YS; Federal Research Center of Nutrition and Biotechnology, Moscow, Russia., Petrov NA; Federal Research Center of Nutrition and Biotechnology, Moscow, Russia., Guseva GV; Federal Research Center of Nutrition and Biotechnology, Moscow, Russia., Mazo VK; Federal Research Center of Nutrition and Biotechnology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Aug; Vol. 175 (4), pp. 454-458. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1007/s10517-023-05884-1
Abstrakt: The choice of an optimal biological model of exogenous hypercholesterolemia is necessary for correct assessment of the cholesterol-lowering properties of bioactive substances and specialized food products and for validity of the experimental results. We studied the effects of cholesterol consumption in the composition of the standard semi-synthetic diet and high-fat high-carbohydrate diet for more than 3 months on lipid and cholesterol metabolism in male Wistar rats. Our findings suggest that cholesterol consumption in both diets led to a significant impairment of lipid and cholesterol metabolism, as well as an increase in insulin resistance in rats.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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