Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.

Autor: Austin-Zimmerman I; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK., Levey DF; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Giannakopoulou O; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK.; UCL Genetics Institute, Division of Biosciences, University College London, London, WC1E 6BT, UK., Deak JD; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Galimberti M; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Adhikari K; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Zhou H; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Denaxas S; Health Data Research UK, Institute of Health Informatics, University College London, London, NW1 2DA, UK., Irizar H; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK.; Department of Genetics & Genomic Sciences and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kuchenbaecker K; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK.; UCL Genetics Institute, Division of Biosciences, University College London, London, WC1E 6BT, UK., McQuillin A; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK., Concato J; School of Medicine, Yale University, New Haven, CT, 06511, USA.; Office of Medical Policy, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD, USA., Buysse DJ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, 02130, USA.; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Gottlieb DJ; VA Boston Healthcare System, 1400 VFW Parkway (111PI), West Roxbury, MA, 02132, USA.; Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Polimanti R; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Stein MB; Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.; Departments of Psychiatry and Herbert Wertheim School of Public Health, University of California, San Diego, La Jolla, CA, USA., Bramon E; Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, W1T 7BN, UK.; Institute of Cognitive Neuroscience, University College London, London, UK., Gelernter J; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. joel.gelernter@yale.edu.; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA. joel.gelernter@yale.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Sep 28; Vol. 14 (1), pp. 6059. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1038/s41467-023-41249-y
Abstrakt: Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (r g = 0.16 ± 0.04; p = 0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation reveals a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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