Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures.

Autor: Hu LS; Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA. hu.leland@mayo.edu.; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA. hu.leland@mayo.edu.; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA. hu.leland@mayo.edu., D'Angelo F; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. fxd317@med.miami.edu., Weiskittel TM; Mayo Clinic Alix School of Medicine Minnesota, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Caruso FP; Department of Electrical Engineering and Information Technologies, University of Naples, 'Federico II', I-80128, Naples, Italy.; BIOGEM Institute of Molecular Biology and Genetics, I-83031, Ariano Irpino, Italy., Fortin Ensign SP; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.; Department of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA., Blomquist MR; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Alix School of Medicine Arizona, Scottsdale, AZ, USA., Flick MJ; Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA.; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.; Mayo Clinic Alix School of Medicine Arizona, Scottsdale, AZ, USA., Wang L; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Sereduk CP; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Meng-Lin K; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., De Leon G; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Nespodzany A; Department of Neuroimaging Research, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA., Urcuyo JC; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Gonzales AC; Department of Neuroimaging Research, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA., Curtin L; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Lewis EM; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA., Singleton KW; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Dondlinger T; Imaging Biometrics, LLC, Elm Grove, Milwaukee, USA., Anil A; Department of Neuroimaging Research, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA., Semmineh NB; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Noviello T; Department of Electrical Engineering and Information Technologies, University of Naples, 'Federico II', I-80128, Naples, Italy.; BIOGEM Institute of Molecular Biology and Genetics, I-83031, Ariano Irpino, Italy., Patel RA; Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA., Wang P; Quantitative Health Sciences, Mayo Clinic Arizona, Scottsdale, AZ, USA., Wang J; Division of Applied Oral Sciences & Community Dental Care, The University of Hong Kong, Hong Kong SAR, China., Eschbacher JM; Department of Neuropathology, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA., Hawkins-Daarud A; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Jackson PR; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Grunfeld IS; Department of Psychology, Hunter College, The City University of New York, New York, NY, USA.; Department of Psychology, The Graduate Center, The City University of New York, New York, NY, USA., Elrod C; Avinger Incorporated, Redwood City, CA, USA., Mazza GL; Quantitative Health Sciences, Mayo Clinic Arizona, Scottsdale, AZ, USA., McGee SC; Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA., Paulson L; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Clark-Swanson K; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Lassiter-Morris Y; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Smith KA; Department of Neurosurgery, Barrow Neurological Institute, Dignity Health, Phoenix, AZ, USA., Nakaji P; Department of Neurosurgery, Banner University Medical Center, University of Arizona, Phoenix, AZ, USA., Bendok BR; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Zimmerman RS; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Krishna C; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Patra DP; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Patel NP; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Lyons M; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Neal M; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Donev K; Department of Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA., Mrugala MM; Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA., Porter AB; Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA., Beeman SC; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA., Jensen TR; Jensen Informatics LLC, Shorewood, WI, USA., Schmainda KM; Departments of Biophysics and Radiology, Medical College of Wisconsin, Milwaukee, WI, USA., Zhou Y; Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA., Baxter LC; Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA.; Departments of Psychiatry and Psychology, Mayo Clinic, AZ, USA., Plaisier CL; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA., Li J; H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Lasorella A; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Quarles CC; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Swanson KR; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA.; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA., Ceccarelli M; Department of Public Health Sciences, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. mxc2982@miami.edu., Iavarone A; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. axi435@med.miami.edu., Tran NL; Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA. Tran.Nhan@mayo.edu.; Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA. Tran.Nhan@mayo.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Sep 28; Vol. 14 (1), pp. 6066. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1038/s41467-023-41559-1
Abstrakt: Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional tumor biopsies, including 111 from the NE, across 68 HGG patients. Whole exome and RNA sequencing uncover unique genomic alterations to unresectable invasive NE tumor, including subclonal events, which inform genomic models predictive of geographic evolution. Infiltrative NE tumor is alternatively enriched with tumor cells exhibiting neuronal or glycolytic/plurimetabolic cellular states, two principal transcriptomic pathway-based glioma subtypes, which respectively demonstrate abundant private mutations or enrichment in immune cell signatures. These NE phenotypes are non-invasively identified through normalized K2 imaging signatures, which discern cell size heterogeneity on dynamic susceptibility contrast (DSC)-MRI. NE tumor populations predicted to display increased cellular proliferation by mean diffusivity (MD) MRI metrics are uniquely associated with EGFR amplification and CDKN2A homozygous deletion. The biophysical mapping of infiltrative HGG potentially enables the clinical recognition of tumor subpopulations with aggressive molecular signatures driving tumor progression, thereby informing precision medicine targeting.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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