Synthesis and diverse biological activities of substituted indole β-carbolines: a review.

Autor: Zulkifli SZ; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA, Cawangan Selangor, Bandar Puncak Alam, Selangor, Malaysia.; Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia., Pungot NH; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA, Cawangan Selangor, Bandar Puncak Alam, Selangor, Malaysia.; Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia., Saaidin AS; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA, Cawangan Selangor, Bandar Puncak Alam, Selangor, Malaysia., Jani NA; Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kuala Pilah, Negeri Sembilan, Malaysia., Mohammat MF; Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi MARA, Cawangan Selangor, Bandar Puncak Alam, Selangor, Malaysia.; Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Nov; Vol. 38 (21), pp. 3793-3806. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1080/14786419.2023.2261141
Abstrakt: β-Carboline bearing indole is one of the heterocyclic compounds that play a vital role in medicinal chemistry with various pharmacological effects such as anticancer, anti-acetylcholinesterase, anti-inflammation, antimalarial, antibacterial, anti-diabetic, and antioxidant. Over the last two decades, many studies on the synthesis and biological activity of indole β-carboline compounds have been conducted yet there is no appropriate data summary has been presented. Thus, the goal of this review was to highlight the synthesis pathway and bioactivity of substituted indole β-carboline reported from 2005 to date. In addition, this will encourage further investigation into the synthesis and evaluation of new indole β-carboline, in the hope of contributing to the development of potentially new medications for the treatment of various ailments.
Databáze: MEDLINE