The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection.

Autor:	Alberto S; Nuclear Medicine Unit, Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University of Rome 'Sapienza,' Rome, Italy., Ordonez AA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland., Arjun C; Radiopharmaceutical Program, Board of Radiation and Isotope Technology, Mumbai, India., Aulakh GK; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Beziere N; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Tübingen, Germany., Dadachova E; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Ebenhan T; Nuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa., Granados U; Department of Nuclear Medicine, Hospital Internacional de Colombia-Fundación Cardiovascular de Colombia, Piedecuesta, Colombia., Korde A; Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria., Jalilian A; Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria., Lestari W; National Nuclear Energy Agency, South Tangerang, Indonesia., Mukherjee A; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India., Petrik M; Institute of Molecular and Translational Medicine and Czech Advanced Technology and Research Institute, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic., Sakr T; Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt., Cuevas CLS; Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Mexico., Welling MM; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; and., Zeevaart JR; Nuclear Medicine, University of Pretoria, and Radiochemistry, Applied Radiation, South African Nuclear Energy Corporation, Pelindaba, South Africa., Jain SK; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wilson DM; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California david.m.wilson@ucsf.edu.
Jazyk:	angličtina
Zdroj:	Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2023 Nov; Vol. 64 (11), pp. 1676-1682. Date of Electronic Publication: 2023 Sep 28.
DOI:	10.2967/jnumed.123.265906
Abstrakt:	The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. The meeting focused largely on bacterial pathogens. The group discussed and evaluated the advantages and disadvantages of several radiopharmaceuticals, as well as the science driving various imaging approaches. The main objective was to understand why few infection-targeted radiotracers are used in clinical practice despite the urgent need to better characterize bacterial infections. This article summarizes the resulting consensus, at least among the included scientists and countries, on the current status of radiopharmaceutical development for infection imaging. Also included are opinions and recommendations regarding current research standards in this area. This and future International Atomic Energy Agency-sponsored collaborations will advance the goal of providing the medical community with innovative, practical tools for the specific image-based diagnosis of infection. (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)
Databáze:	MEDLINE
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