Influence of prepartum dietary cation-anion difference and the magnitude of calcium decline at the onset of lactation on mineral metabolism and physiological responses.

Autor:	Connelly MK; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706., Harris RMR; Australian National University, Canberra 2601, Australia., Kuehnl J; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706., Andrade JPN; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706., Andrade FS; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706., Henschel S; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706., Block E; Arm & Hammer Animal Nutrition, Princeton, NJ 08543., Lean IJ; Scibus, Camden, NSW 2570, Australia., Hernandez LL; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706. Electronic address: llhernandez@wisc.edu.
Jazyk:	angličtina
Zdroj:	Journal of dairy science [J Dairy Sci] 2024 Feb; Vol. 107 (2), pp. 1228-1243. Date of Electronic Publication: 2023 Sep 26.
DOI:	10.3168/jds.2023-23588
Abstrakt:	The onset of lactation is characterized by substantially altered calcium (Ca) metabolism; recently, emphasis has been placed on understanding the dynamics of blood Ca in the peripartal cow in response to this change. Thus, the aim of our study was to delineate how prepartum dietary cation-anion difference (DCAD) diets and the magnitude of Ca decline at the onset of lactation altered blood Ca dynamics in the periparturient cow. Thirty-two multiparous Holstein cows were blocked by parity, previous 305-d milk yield and expected parturition date, and randomly allocated to either a positive (+120 mEq/kg) or negative (-120 mEq/kg) DCAD diet from 251 d of gestation until parturition (n = 16/diet). Immediately after parturition cows were continuously infused for 24 h with (1) an intravenous solution of 10% dextrose or (2) Ca gluconate (CaGlc) to maintain blood ionized (iCa) concentrations at ∼1.2 mM (normocalcemia) to form 4 treatment groups (n = 8/treatment). Blood was sampled every 6 h from 102 h before parturition until 96 h after parturition and every 30 min during 24 h continuous infusion. Cows fed a negative DCAD diet prepartum exhibited a less pronounced decline in blood iCa approaching parturition with lesser magnitude of decline relative to positive DCAD-fed cows. Cows fed a negative DCAD diet prepartum required lower rates of CaGlc infusion to maintain normocalcemia in the 24 h postpartum relative to positive DCAD-fed cows. Infusion of CaGlc disrupted blood Ca and P dynamics in the immediate 24 h after parturition and in the days following infusion. Collectively, these data demonstrate that prepartum negative DCAD diets facilitate a more transient hypocalcemia and improve blood Ca profiles at the onset of lactation whereas CaGlc infusion disrupts mineral metabolism. (The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
Databáze:	MEDLINE
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