Efficacy of a Novel Electroconductive Matrix To Treat Muscle Atrophy and Fat Accumulation in Chronic Massive Rotator Cuff Tears of the Shoulder.

Autor:	Shemshaki NS; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, Connecticut 06030, United States.; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States., Kan HM; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, Connecticut 06030, United States.; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut 06030, United States., Barajaa MA; Department of Biomedical Engineering, Imam Abdulrahman Bin Faisal University, Dammam 31451, Saudi Arabia., Lebaschi A; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, United States., Otsuka T; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, Connecticut 06030, United States.; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut 06030, United States., Mishra N; Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut 06269, United States.; Connecticut Veterinary Medical Diagnostic Laboratory, Storrs, Connecticut 06269, United States., Nair LS; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, Connecticut 06030, United States.; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.; Department of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.; Department of Chemical & Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States., Laurencin CT; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, Connecticut 06030, United States.; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.; Department of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.; Department of Chemical & Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.
Jazyk:	angličtina
Zdroj:	ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2023 Oct 09; Vol. 9 (10), pp. 5782-5792. Date of Electronic Publication: 2023 Sep 28.
DOI:	10.1021/acsbiomaterials.3c00585
Abstrakt:	The high retear rate after a successful repair of the rotator cuff (RC) is a major clinical challenge. Muscle atrophy and fat accumulation of RC muscles over time adversely affect the rate of retear. Since current surgical techniques do not improve muscle degenerative conditions, new treatments are being developed to reduce muscle atrophy and fat accumulation. In the previous study, we have shown the efficacy of aligned electroconductive nanofibrous fabricated by coating poly(3,4-ethylene dioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) nanoparticles onto aligned poly(ε-caprolactone) (PCL) electrospun nanofibers (PEDOT:PSS matrix) to reduce muscle atrophy in acute and subacute models of RC tears (RCTs). In this study, we further evaluated the efficacy of the PEDOT:PSS matrix to reduce muscle atrophy and fat accumulation in a rat model of chronic massive full-thickness RCTs (MRCTs). The matrices were transplanted on the myotendinous junction to the belly of the supraspinatus and infraspinatus muscles at 16 weeks after MRCTs. The biomechanics and histological assessments showed the potential of the PEDOT:PSS matrix to suppress the progression of muscle atrophy, fat accumulation, and fibrosis in both supraspinatus and infraspinatus muscles at 24 and 32 weeks after MRCTs. We also demonstrated that the PEDOT:PSS matrix implantation significantly improved the tendon morphology and tensile properties compared with current surgical techniques.
Databáze:	MEDLINE
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