The Influence of the Synthetic Organoselenium Preparation 974zh on the Immunogenic Activity of Yersinia pestis EV Vaccine Strain NIIEG.

Autor: Dubrovina VI; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru., Yur'eva OV; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Starovoitova TP; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Pyatidesyatnikova AB; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Ivanova TA; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Grigor'evykh AV; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Pescherova RI; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Balakhonov SV; Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Aug; Vol. 175 (4), pp. 473-476. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1007/s10517-023-05889-w
Abstrakt: In the present study, a stimulating effect of a new synthetic organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonandibromide (974zh) on the immunogenic activity of the vaccine strain Yersinia pestis EV NIIEG was revealed. After infection with the virulent plague strain, the survival rate of laboratory mice immunized with the vaccine strain grown on Hottinger's agar in the presence of 974zh (300 μg/ml) increased in comparison with control animals immunized with the Y. pestis EV NIIEG culture grown on agar without the studied compound. Plasmid screening of cultures grown on medium with and without 974zh showed that plasmid DNA of Y. pestis EV culture grown in the presence of 974zh had broader bands in the control grown without 974zh. This phenomenon can indicate activation of replication of plasmid DNA of Y. pestis EV under the influence of the experimental compound.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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