Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial.

Autor: Roig-Coll F; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Institut de Neurociències, University of Barcelona, Barcelona, Spain., Castells-Sánchez A; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Institut de Neurociències, University of Barcelona, Barcelona, Spain., Monté-Rubio G; Institut de Neurociències, University of Barcelona, Barcelona, Spain.; Medical Psychology Unit, Department of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.; Centre de Medicina Comparativa i Bioimatge (CMCiB), Institut d'Investigació en Ciències de la Salut Germans Trias I Pujol (IGTP), Badalona, Spain., Dacosta-Aguayo R; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain.; Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain., Lamonja-Vicente N; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Institut de Neurociències, University of Barcelona, Barcelona, Spain.; Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain.; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain., Torán-Monserrat P; Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain.; Department of Medicine, Universitat de Girona, Girona, Spain., Pere G; Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain., García-Molina A; Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain.; Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain., Tormos JM; Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain.; Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain., Alzamora MT; Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain., Stavros D; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Institut de Neurociències, University of Barcelona, Barcelona, Spain., Sánchez-Ceron M; Institut de Diagnòstic per la Imatge, Hospital Germans Trias i Pujol, Badalona, Spain., Via M; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.; Institut de Neurociències, University of Barcelona, Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain., Erickson KI; Department of Psychology, University of Pittsburgh, Pittsburgh, USA.; AdventHealth Research Institute, Orlando, FL, USA.; Department of Physical and Sports Education, Faculty of Sport Sciences, PROFITH 'PROmoting FITness and Health Through Physical Activity' Research Group, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain., Mataró M; Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain. mmataro@ub.edu.; Institut de Neurociències, University of Barcelona, Barcelona, Spain. mmataro@ub.edu.; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain. mmataro@ub.edu.
Jazyk: angličtina
Zdroj: European journal of applied physiology [Eur J Appl Physiol] 2024 Mar; Vol. 124 (3), pp. 909-924. Date of Electronic Publication: 2023 Sep 28.
DOI: 10.1007/s00421-023-05319-9
Abstrakt: Introduction: This is a 12-weeks randomized controlled trial examining the effects of aerobic exercise (AE), computerized cognitive training (CCT) and their combination (COMB). We aim to investigate their impact on cardiovascular health and white matter (WM) integrity and how they contribute to the cognitive benefits.
Methods: 109 participants were recruited and 82 (62% female; age = 58.38 ± 5.47) finished the intervention with > 80% adherence. We report changes in cardiovascular risk factors and WM integrity (fractional anisotropy (FA); mean diffusivity (MD)), how they might be related to changes in physical activity, age and sex, and their potential role as mediators in cognitive improvements.
Results: A decrease in BMI (SMD = - 0.32, p = 0.039), waist circumference (SMD = - 0.42, p = 0.003) and diastolic blood pressure (DBP) (SMD = - 0.42, p = 0.006) in the AE group and a decrease in BMI (SMD = - 0.34, p = 0.031) and DBP (SMD = - 0.32, p = 0.034) in the COMB group compared to the waitlist control group was observed. We also found decreased global MD in the CCT group (SMD = - 0.34; p = 0.032) and significant intervention-related changes in FA and MD in the frontal and temporal lobes in the COMB group.
Conclusions: We found changes in anthropometric measures that suggest initial benefits on cardiovascular health after only 12 weeks of AE and changes in WM microstructure in the CCT and COMB groups. These results add evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.
Clinical Trial Registration: ClinicalTrials.gov NCT031123900.
(© 2023. The Author(s).)
Databáze: MEDLINE
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