The Impact of Bilateral Stone Disease on Patients' Disease Progression and Health-Related Quality of Life.

Autor: Raizenne BL; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada., Deyirmendjian C; Faculty of Medicine, Université de Montréal, Montréal, Canada., Lafontaine ML; Faculty of Medicine, Université de Montréal, Montréal, Canada., Balde M; Faculty of Sciences and Technologies, Gaston Berger University, Saint Louis, Senegal., Bechis SK; Department of Urology, University of California San Diego, San Diego, California, USA., Sur RL; Department of Urology, University of California San Diego, San Diego, California, USA., Nakada SY; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Antonelli JA; Division of Urology, Department of Surgery, Duke University, Durham, North Carolina, USA., Streeper NM; Division of Urology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Sivalingam S; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA., Viprakasit DP; Department of Urology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Averch TD; Department of Urology, Palmetto Health USC Medical Group, Columbia, South Carolina, USA., Landman J; University of California Irvine School of Medicine, Orange, California, USA., Chi T; Department of Urology, University of California San Francisco, San Francisco, California, USA., Pais VM; Urology Section, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA., Chew BH; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Bird VG; Department of Urology, University of Florida College of Medicine, Gainesville, Florida, USA., Andonian S; Division of Urology, McGill University Health Center, Montreal, Canada., Canvasser NE; Department of Urology, University of California Davis, Sacramento, California, USA., Harper JD; Department of Urology, University of Washington, Seattle, Washington, USA., Penniston KL; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Bhojani N; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
Jazyk: angličtina
Zdroj: Journal of endourology [J Endourol] 2023 Dec; Vol. 37 (12), pp. 1289-1294.
DOI: 10.1089/end.2023.0132
Abstrakt: Purpose: Patients with recurring kidney stone events can expect significant morbidity and functional impairment. Few studies have evaluated the effect of bilateral kidney stones on disease progression and quality of life. We wanted to determine the association of bilateral stone disease on age of onset, and the impact on number of stone events and individual kidney stone disease-specific health-related quality of life (HRQOL) by analyzing the validated and prospectively collected Wisconsin Stone Quality of Life (WISQOL) database. Materials and Methods: We studied 2906 stone patients from 16 centers in North America after having completed the WISQOL questionnaire from 2014 to 2019. Kidney stone formers were assessed if kidney stones were bilateral or unilateral on imaging. Analysis with a chi-square test compared categorical variables. Bilateral kidney stone disease and its impact on HRQOL were evaluated through a multivariable linear regression model. Results: Of 2906 kidney stone formers, 1340 had unilateral kidney stones and 1566 had bilateral kidney stones. We observed more frequently that patients with bilateral stones had an increased number of depression/anxiety symptoms, renal tubular acidosis, and rheumatoid arthritis (all p  < 0.05). Patients with bilateral stones had a younger mean (standard deviation [SD]) age of kidney stone disease onset (37.2 ± 15.8 vs 46.4 ± 15.9 years of age, p  < 0.001). Bilateral kidney stone formers had a higher mean (SD) number of stone events (11.3 ± 21.8) than unilateral kidney stone formers (3.0 ± 5.1) ( p  < 0.001). Within our multivariable analysis, we found that HRQOL was negatively affected by the presence of bilateral stones for kidney stone patients ( β  = -11.2 [confidence interval: -19.5 to -3.0] points, p  < 0.05). Conclusions: Bilateral kidney stone formers had a younger age of kidney stone disease onset and a higher number of stone events compared with unilateral kidney stone disease formers. The presence of bilateral kidney stone disease negatively impacted HRQOL.
Databáze: MEDLINE
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