The association of upper respiratory infections with neuro-radiological course and attack rate of multiple sclerosis: Results from a large prospective cohort.

Autor:	Ghasemi M; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Farazandeh D; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Amini B; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Sedaghat M; Faculty of Medicine, Razi Educational and Therapeutic Psychiatric Center, University of Social Welfare and Rehabilitation, Tehran, Iran., Najafi A; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Khayatzadeh Kakhki S; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Torabi P; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Jafarimehrabady N; School of Medicine, University of Pavia, Pavia, Italy., Bitaraf A; School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran., Shariati H; Azad University of Medical Science, Tehran, Iran., Gholampour G; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Kazemi S; Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Naser Moghadasi A; Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran., Vajihinejad M; Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis journal - experimental, translational and clinical [Mult Scler J Exp Transl Clin] 2023 Sep 25; Vol. 9 (3), pp. 20552173231196992. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI:	10.1177/20552173231196992
Abstrakt:	Background: Although upper respiratory infections (URIs) are linked to multiple sclerosis (MS) attacks, SARS-COV2 has not been compared to URIs for attack rates. Objectives: This study aimed to evaluate the attack rate and the results of neuroimaging in MS patients with URIs caused by COVID-19 and non-COVID-19 infections (NC-URI). Methods: From May 2020 to April 2021, we followed 362 patients with relapsing-remitting MS in a prospective cohort design. Patients were monitored regularly every 12 weeks; an magnetic resonance imaging (MRI) scan was performed at enrollment and every time a relapse occurred. Poisson analysis was used to determine exacerbation rate ratios (RR) and the MRI parameters were tested using chi-square analysis. Results: 347 patients with an average age of 38 and a female ratio of 86% were included. A RR of 2.24 ( p  < 0.001) was observed for exacerbations during the at-risk period (ARP). Attacks related to COVID-19 (RR = 2.13, p  = 0.001) and NC-URIs (RR = 2.39, p  < 0.001) were comparable regarding the increased risk of exacerbation ( p  = 0.62). Exacerbations within or outside the ARP did not significantly alter the number of baseline GAD-enhancing lesions ( p  > 0.05 for both). Conclusion: COVID-19 has been shown to increase the risk of MS exacerbations, like other viral URIs. Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2023.)
Databáze:	MEDLINE
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