Evaluation of Aqueous Flare in Graves' Ophthalmopathy and its Relationship with Thyroid Hormones, Antibodies, and Clinical Activity Score.
Autor: | Topcu H; University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye., Atik BK; University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye., Ozkocak BY; University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye., Efe AC; University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye., Ulas MG; University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye., Cabuk KS; University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye. |
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Jazyk: | angličtina |
Zdroj: | Beyoglu eye journal [Beyoglu Eye J] 2023 Sep 13; Vol. 8 (3), pp. 208-213. Date of Electronic Publication: 2023 Sep 13 (Print Publication: 2023). |
DOI: | 10.14744/bej.2023.80557 |
Abstrakt: | Objectives: The aim of this study was to assess intraocular inflammation in patients with active and inactive Graves' ophthalmopathy (GO) using an aqueous laser flash meter and to assess its relationship with thyroid hormones, antibodies, and clinical activity score (CAS). Methods: Forty patients (29 females and 11 males) were included in the study. The patients were divided into two groups according to CAS; patients with CAS <3 (inactive) were included in Group 1 and patients with CAS ≥3 (active) were included in Group 2. The laser flare meter was used to measure the flare of aqueous humor. Each patient's ocular findings, thyroid hormone, and antibody levels were also recorded. Results: The mean age of patients was 46.88±11.79 years in Group 1 and 44.50±12.59 years in Group 2 (p=0.555). The mean CAS was 0.88±0.65 in Group 1 and 3.57±0.85 in Group 2 (p<0.001). The mean aqueous flare was 6.5±2.2 ph/ms in Group 1 and 7.0±6.4 ph/ms in Group 2 (p=0.73). Hertel exophthalmometry, intraocular pressure (IOP), antithyroglobulin antibody, and thyroid stimulating hormone receptor antibody (TRAb) levels were similar in both groups (each p>0.05). There was no correlation between aqueous flare value and CAS, Hertel exophthalmometry, IOP, thyroid hormone, and antibody levels (each p>0.05). There was a significant correlation between CAS and antibody levels (each p<0.05). Conclusion: Flare values that are not much above the normal range may be an indication that intraocular inflammation is not elevated in GO patients. This suggests that the damage to the blood-aqueous barrier in these patients is not severe enough to increase intraocular inflammation. Competing Interests: Conflict of Interest: None declared. (Copyright: © 2023 by Beyoglu Eye Training and Research Hospital.) |
Databáze: | MEDLINE |
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