Sensitive and Selective Dual-Mode Responses to Reactive Oxygen Species by Chiral Manganese Dioxide Nanoparticles for Antiaging Skin.

Autor: Qu A; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Chen Q; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Sun M; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Xu L; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Hao C; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Xu C; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China., Kuang H; International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Jiangsu, 214122, China.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Feb; Vol. 36 (5), pp. e2308469. Date of Electronic Publication: 2023 Dec 05.
DOI: 10.1002/adma.202308469
Abstrakt: Excessive accumulation of reactive oxygen species (ROS) can lead to oxidative stress and oxidative damage, which is one of the important factors for aging and age-related diseases. Therefore, real-time monitoring and the moderate elimination of ROS is extremely important. In this study, a ROS-responsive circular dichroic (CD) at 553 nm and magnetic resonance imaging (MRI) dual-signals chiral manganese oxide (MnO 2 ) nanoparticles (NPs) are designed and synthesized. Both the CD and MRI signals show excellent linear ranges for intracellular hydrogen peroxide (H 2 O 2 ) concentrations, with limits of detection (LOD) of 0.0027 nmol/10 6 cells and 0.016 nmol/10 6 cells, respectively. The lower LOD achieved with CD detection may be attributable to its higher anti-interference capability from the intracellular matrix. Importantly, ROS-induced cell aging is intervened by chiral MnO 2 NPs via redox reactions with excessive intracellular ROS. In vivo experiments confirm that chiral MnO 2 NPs effectively eliminate ROS in skin tissue, reduce oxidative stress levels, and alleviate skin aging. This approach provides a new strategy for the diagnosis and treatment of age-related diseases.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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