| Autor: |
Nunes PF; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., da Cruz Coelho E; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., da Silva JR; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., da Silva Costa CC; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., Sampaio RMA; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., Frade PCR; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., Ponteira NA; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil., da Cruz SS; Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém 66063-240, PA, Brazil., Seabra AD; Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém 66063-240, PA, Brazil., Carneiro DM; Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém 66063-240, PA, Brazil., Burbano RMR; Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém 66063-240, PA, Brazil., Martins LC; Núcleo de Medicina Tropical, Laboratório de Patologia Clínica das Doenças Tropicais, Universidade Federal do Pará, Belém 66055-240, PA, Brazil. |
| Abstrakt: |
Coinfection of HPgV-1 with hepatitis C virus (HCV) is common due to shared modes of transmission, with a prevalence of HPgV-1 viremia of approximately 20% among individuals with chronic HCV infection. The aim of the present study was to estimate the prevalence of HPgV-1 RNA and circulating genotypes in patients with hepatitis C from a health service located in the city of Belém, in the state of Pará, Northern Brazil. A total of 147 samples were included in the study from February to December 2019. Among the participants, 72.1% (106/147) were monoinfected with HCV, with detectable HCV viral RNA, and 27.9% (41/147) were coinfected with HCV/HPgV-1. The most frequently found genotypes were HPgV-1 genotypes 1 and 2 (36.6% and 63.4%), respectively. While for HCV there was a predominance of genotypes 1 and 3 (58.5% and 41.5%). No significant differences were found when comparing any risk, sociodemographic, or clinical factors between groups. Also, there was no statistically significant difference when relating the viral genotypes of both agents. This study indicated that the prevalence of infection by HPgV-1 is high in HCV carriers in Belém, Pará, and probably does not change the clinical course of HCV infection, however, further studies are still needed. |
