Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome.

Autor: Bezerra WP; Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil., Salmeron ACA; Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaiba 59280-000, RN, Brazil., Branco ACCC; Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo 05403-000, SP, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil., Morais IC; Virology Laboratory, Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal 59078-190, RN, Brazil., de Farias Sales VS; Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Machado PRL; Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Souto JT; Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil., de Araújo JMG; Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil.; Virology Laboratory, Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal 59078-190, RN, Brazil., Guedes PMDM; Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil., Sato MN; Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo 05403-000, SP, Brazil., Nascimento MSL; Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2023 Aug 29; Vol. 15 (9). Date of Electronic Publication: 2023 Aug 29.
DOI: 10.3390/v15091832
Abstrakt: Congenital Zika Syndrome (CZS) is associated with an increased risk of microcephaly in affected children. This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to CZS. Gene expression quantified by qPCR in whole blood samples showed an increase in IFNγ and IL-13 transcripts in children affected with microcephaly compared to the control group. The microcephaly group exhibited significantly decreased CCL2 and CXCL8 levels in serum, quantified by CBA assay. An allergic profile questionnaire revealed a high prevalence of allergies in the microcephaly group. In accordance, elevated serum IgE level measured by the Proquantum Immunoassay was observed in children affected with microcephaly compared to the control group. Altogether, these findings show a persistent systemic inflammation in children with microcephaly due to CZS and suggest a possible impairment in leukocyte migration caused by low production of CCL2 and CXCL8, in addition to high levels of IgE associated with high prevalence of allergies. The dysregulation of inflammatory genes and chemokines underscores the importance of understanding the immunological characteristics of CZS. Further investigation into the long-term consequences of systemic inflammation in these children is crucial for developing appropriate therapeutic strategies and tailored vaccination protocols.
Databáze: MEDLINE
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