Role of elements in pathophysiology of hypertension and antihypertensive drug development.

Autor: Arora RB, Roy S, Khan SU
Jazyk: angličtina
Zdroj: Acta pharmacologica et toxicologica [Acta Pharmacol Toxicol (Copenh)] 1986; Vol. 59 Suppl 7, pp. 344-7.
DOI: 10.1111/j.1600-0773.1986.tb02776.x
Abstrakt: Cadmium and Zinc levels were determined in 100 patients of Essential hypertension by Atomic Absorption Spectrophotometer. It was shown that the mean levels of Serum cadmium were 43.34% +/- 6.5% higher and zinc were 28.42% +/- 5.4% lower in hypertensive when compared with normotensive controls. A statistically significant relationship between the height of diastolic blood pressure and Serum cadmium levels was observed. Ajmaloon a preparation from Rauvolfia serpentina with corrective herbs lowered the blood pressure effectively and significantly P less than 0.001. The side effects were minimal. It also tends to decrease the elevated serum cadmium levels in hypertensive individuals. A plea for development of Catecholamine depleting agents as drug for hypertension is advanced.
Databáze: MEDLINE
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