Recent Advances in the Management Strategies for Buruli Ulcers.

Autor: Popa GL; Department of Microbiology, Faculty of Dental Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Colentina Clinical Hospital, 020125 Bucharest, Romania., Muntean AA; Department of Microbiology II, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; 'Cantacuzino' National Military Medical Institute for Research and Development, 050096 Bucharest, Romania., Popa MI; Department of Microbiology II, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; 'Cantacuzino' National Military Medical Institute for Research and Development, 050096 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2023 Aug 27; Vol. 12 (9). Date of Electronic Publication: 2023 Aug 27.
DOI: 10.3390/pathogens12091088
Abstrakt: Buruli ulcer (BU) is a bacterial skin infection that is caused by Mycobacterium ulcerans and mainly affects people who reside in the rural areas of Africa and in suburban and beach resort communities in Australia. The infection typically begins as a painless papule or nodule that gradually develops into a large ulcer that can cause substantial impairment, damaging soft tissues and even bones. Early detection and immediate treatment are crucial to preventing further tissue damage and any potential complications, although it is worth noting that access to proper therapeutic resources can be limited in certain areas. The most commonly used antibiotics for treating BU are rifampicin, streptomycin, and clarithromycin; efforts have recently been made to introduce new treatments that increase the effectiveness and adherence to therapy. This article presents the latest research and management strategies regarding BU, providing an updated and intriguing perspective on this topic.
Databáze: MEDLINE