| Autor: |
Horowitz RI; Lyme and Tick-Borne Diseases Working Group, New York State Department of Health, Albany, NY 12224, USA.; Hudson Valley Healing Arts Center, Hyde Park, NY 12538, USA., Fallon J; Hudson Valley Healing Arts Center, Hyde Park, NY 12538, USA., Freeman PR; Hudson Valley Healing Arts Center, Hyde Park, NY 12538, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Microorganisms [Microorganisms] 2023 Sep 12; Vol. 11 (9). Date of Electronic Publication: 2023 Sep 12. |
| DOI: |
10.3390/microorganisms11092301 |
| Abstrakt: |
Twenty-five patients with relapsing and remitting Borreliosis, Babesiosis, and bartonellosis despite extended anti-infective therapy were prescribed double-dose dapsone combination therapy (DDDCT), followed by one or several courses of High Dose Dapsone Combination Therapy (HDDCT). A retrospective chart review of these 25 patients undergoing DDDCT therapy and HDDCT demonstrated that 100% improved their tick-borne symptoms, and patients completing 6-7 day pulses of HDDCT had superior levels of improvement versus 4-day pulses if Bartonella was present. At the completion of treatment, 7/23 (30.5%) who completed 8 weeks of DDDCT followed by a 5-7 day pulse of HDDCT remained in remission for 3-9 months, and 3/23 patients (13%) who recently finished treatment were 1 ½ months in full remission. In conclusion, DDDCT followed by 6-7 day pulses of HDDCT could represent a novel, effective anti-infective strategy in chronic Lyme disease/Post Treatment Lyme Disease Syndrome (PTLDS) and associated co-infections, including Bartonella , especially in individuals who have failed standard antibiotic protocols. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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