| Autor: |
Jin H; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea., Park SK; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea., Yun YG; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea., Song NE; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea., Baik SH; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
Microorganisms [Microorganisms] 2023 Sep 11; Vol. 11 (9). Date of Electronic Publication: 2023 Sep 11. |
| DOI: |
10.3390/microorganisms11092285 |
| Abstrakt: |
Nitric oxide (NO) is a free radical associated with physiological functions such as blood pressure regulation, cardiovascular health, mitochondrial production, calcium transport, oxidative stress, and skeletal muscle repair. This study aimed to isolate Latilactobacillus curvatus strains with enhanced NO production from the traditional Korean fermented food, jangajji, and evaluate their probiotic properties for industrial purposes. When cells were co-cultured with various bacterial stimulants, NO production generally increased, and NO synthesis was observed in the range of 20-40 mg/mL. The selected strains of Lat. curvatus were resistant to acid and bile conditions and with variable effectiveness (1-14%) in adhering to Caco-2 cells. Most bacterial strains can inhibit the growth of various pathogens. In addition, they are capable of reducing cholesterol levels via assimilation of cholesterol at 10-50%. Among the selected NO synthases from Lat. curvatus strains, the strain JBCC38 showed the highest capacity to scavenge ABTS (30.1%) and DPPH radicals (39.4%). Moreover, these strains exhibited immunomodulatory properties. The production of TNF-α and IL-6 in the macrophages treated with various bacterial stimulants was induced in all the selected strains. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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