| Autor: |
Gallenga CE; Department of Medical Sciences Doctoral Course Molecular Medicine, University of Ferrara, 44121 Ferrara, Italy.; Ophthalmology Unit, University-Hospital Cona, 44124 Ferrara, Italy., Maritati M; Bone and Infections Lab, Santa Maria Maddalena NH, Occhiobello, 45030 Rovigo, Italy.; Department of Medical Sciences, Infectious Diseases Unit, University of Ferrara, 44121 Ferrara, Italy., Mura M; Ophthalmology Unit, University-Hospital Cona, 44124 Ferrara, Italy.; Department of Translational Medicine and for the Romagna, Ophthalmology, University of Ferrara, 44121 Ferrara, Italy., Di Virgilio F; Department of Medical Sciences Doctoral Course Molecular Medicine, University of Ferrara, 44121 Ferrara, Italy.; Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy., Conti P; School of Medicine, Immunology, G. D'Annunzio University, Chieti-Pescara, 66100 Chieti, Italy.; Molecular Pharmacology and Drug Discovery Laboratory, School of Medicine, Tufts University, Boston, MA 02111, USA., Contini C; Department of Medical Sciences, Section Dermatology and Infectious Diseases, University of Ferrara, 44124 Ferrara, Italy. |
| Abstrakt: |
Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the 'asymptomatic' patient. |
