| Autor: |
Ciccone MM; Cardiology Unit, Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Lepera ME; Cardiology Unit, Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Guaricci AI; Cardiology Unit, Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Forleo C; Cardiology Unit, Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Cafiero C; Area of Molecular Pathology, Anatomic Pathology Unit, Fabrizio Spaziani Hospital, 03100 Frosinone, Italy., Colella M; Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Palmirotta R; Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Santacroce L; Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy. |
| Abstrakt: |
In recent years, the increasing number of studies on the relationship between the gut microbiota and atherosclerosis have led to significant interest in this subject. The gut microbiota, its metabolites (metabolome), such as TMAO, and gut dysbiosis play an important role in the development of atherosclerosis. Furthermore, inflammation, originating from the intestinal tract, adds yet another mechanism by which the human ecosystem is disrupted, resulting in the manifestation of metabolic diseases and, by extension, cardiovascular diseases. The scientific community must understand and elucidate these mechanisms in depth, to gain a better understanding of the relationship between atherosclerosis and the gut microbiome and to promote the development of new therapeutic targets in the coming years. This review aims to present the knowledge acquired so far, to trigger others to further investigate this intriguing topic. |
