Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed-Case Report and Literature Review.

Autor: Lipiński Ł; Students' Scientific Society at the Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Lipińska J; Students' Scientific Society at the Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Kowalczuk M; Students' Scientific Society at the Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Kopeć I; Students' Scientific Society at the Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Woźniak MM; Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Mitek-Palusińska J; Department of Pediatric Radiology, Medical University of Lublin, 20-093 Lublin, Poland., Mitura-Lesiuk M; Department of Pediatric Hematology, Oncology and Transplantation, Medical University of Lublin, 20-093 Lublin, Poland.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Sep 21; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 21.
DOI: 10.3390/jcm12186092
Abstrakt: Nonspecific gastrointestinal symptoms remain a problem for pediatricians because, out of a thousand trivial cases, there are rare diseases that require in-depth diagnostics and extensive knowledge to identify them. These complaints may be caused by a neoplastic process. We present the case of a 5-year-old boy whose diagnostic pathway lasted about 3 months. He was admitted to hospital due to severe abdominal pain. Physical examination revealed a bloated, hard, and painful abdomen. In the standing X-ray, the features of intestinal obstruction were visualized. An ultrasound examination showed a possible malignant lesion in the location of the left adrenal gland. After the surgical removal of the pathological mass and histopathological examination, the diagnosis of ganglioneuroblastoma intermixed was made. This tumor, along with neuroblastoma, ganglioneuroma, and ganglioneuroblastoma nodular, belongs to neuroblastic tumors (NTs), which originate from primitive cells of the sympathetic nervous system. NTs are quite rare, but they are still the majority of extracranial solid tumors in children, and their symptoms often appear relatively late when the neoplastic process is already advanced. The purpose of this review is to present current information about ganglioneuroblastoma, with a special emphasis on nonspecific gastrointestinal symptoms as first sign of this tumor and its diagnostics.
Databáze: MEDLINE
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