Patients Hospitalized for COVID-19 in the Periods of Delta and Omicron Variant Dominance in Greece: Determinants of Severity and Mortality.

Autor: Karageorgou V; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Papaioannou AI; 1st Respiratory Medicine Department, 'Sotiria' Chest Hospital, Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece., Kallieri M; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Blizou M; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Lampadakis S; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Sfika M; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Krouskos A; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Papavasileiou V; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Strakosha F; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Vandorou KT; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Siozos P; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Moustaka Christodoulou M; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Kontonasiou G; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Apollonatou V; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Antonogiannaki EM; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Kyriakopoulos C; Respiratory Medicine Department, University Hospital of Ioannina, 45500 Ioannina, Greece., Aggelopoulou C; Respiratory Medicine Department, University Hospital of Ioannina, 45500 Ioannina, Greece., Chronis C; Respiratory Medicine Department, University Hospital of Ioannina, 45500 Ioannina, Greece., Kostikas K; Respiratory Medicine Department, University Hospital of Ioannina, 45500 Ioannina, Greece., Koukaki E; 1st Respiratory Medicine Department, 'Sotiria' Chest Hospital, Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece., Sotiropoulou Z; 1st Respiratory Medicine Department, 'Sotiria' Chest Hospital, Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece., Athanasopoulou A; 1st Respiratory Medicine Department, 'Sotiria' Chest Hospital, Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece., Bakakos P; 1st Respiratory Medicine Department, 'Sotiria' Chest Hospital, Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece., Schoini P; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Alevrakis E; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Poupos S; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Chondrou E; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Tsoukalas D; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Chronaiou A; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Tsoukalas G; 4th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Koukidou S; 5th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Hillas G; 5th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Dimakou K; 5th Respiratory Medicine Department, 'Sotiria' Chest Hospital, 11527 Athens, Greece., Roukas K; COVID-19 Clinic, General Hospital G. Papanikolaou, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece., Nakou I; COVID-19 Clinic, General Hospital G. Papanikolaou, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece., Chloros D; COVID-19 Clinic, General Hospital G. Papanikolaou, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece., Fouka E; COVID-19 Clinic, General Hospital G. Papanikolaou, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece., Papiris SA; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Loukides S; 2nd Respiratory Medicine Department, 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Sep 11; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 11.
DOI: 10.3390/jcm12185904
Abstrakt: Background: Coronavirus disease 2019 (COVID-19) has been a pandemic since 2020, and depending on the SARS-CoV-2 mutation, different pandemic waves have been observed. The aim of this study was to compare the baseline characteristics of patients in two phases of the pandemic and evaluate possible predictors of mortality.
Methods: This is a retrospective multicenter observational study that included patients with COVID-19 in 4 different centers in Greece. Patients were divided into two groups depending on the period during which they were infected during the Delta and Omicron variant predominance.
Results: A total of 979 patients (433 Delta, 546 Omicron) were included in the study (median age 67 years (54, 81); 452 [46.2%] female). Compared to the Omicron period, the patients during the Delta period were younger (median age [IQR] 65 [51, 77] vs. 70 [55, 83] years, p < 0.001) and required a longer duration of hospitalization (8 [6, 13] vs. 7 [5, 12] days, p = 0.001), had higher procalcitonin levels (ng/mL): 0.08 [0.05, 0.17] vs. 0.06 [0.02, 0.16], p = 0.005, ferritin levels (ng/mL): 301 [159, 644] vs. 239 [128, 473], p = 0.002, C- reactive protein levels (mg/L): 40.4 [16.7, 98.5] vs. 31.8 [11.9, 81.7], p = 0.003, and lactate dehydrogenase levels (U/L): 277 [221, 375] vs. 255 [205, 329], p < 0.001. The Charlson Comorbidity Index was lower (3 [0, 5] vs. 4 [1, 6], p < 0.001), and the extent of disease on computed tomography (CT) was greater during the Delta wave ( p < 0.001). No evidence of a difference in risk of death or admission to the intensive care unit was found between the two groups. Age, cardiovascular events, acute kidney injury during hospitalization, extent of disease on chest CT, D-dimer, and neutrophil/lymphocyte ratio values were identified as independent predictors of mortality for patients in the Delta period. Cardiovascular events and acute liver injury during hospitalization and the PaO 2 /FiO 2 ratio on admission were identified as independent predictors of mortality for patients in the Omicron period.
Conclusions: In the Omicron wave, patients were older with a higher number of comorbidities, but patients with the Delta variant had more severe disease and a longer duration of hospitalization.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje