Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma.

Autor: Hwang BY; Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 03722, Republic of Korea., Seo JW; Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 03722, Republic of Korea., Muftuoglu C; Institute of Health Sciences, Department of Basic Oncology, Ege University, Izmir 35040, Turkey.; Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir 35040, Turkey., Mert U; Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir 35040, Turkey.; Ataturk Health Care Vocational School, Ege University, Izmir 35040, Turkey., Guldaval F; Chest Disease Department, Izmir Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Izmir 35170, Turkey., Asadi M; Institute of Health Sciences, Department of Basic Oncology, Ege University, Izmir 35040, Turkey.; Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir 35040, Turkey., Karakus HS; Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir 35040, Turkey., Goksel T; Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir 35040, Turkey.; Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir 35040, Turkey., Veral A; Department of Pathology, Faculty of Medicine, Ege University, Izmir 35040, Turkey., Caner A; Institute of Health Sciences, Department of Basic Oncology, Ege University, Izmir 35040, Turkey.; Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir 35040, Turkey.; Department of Parasitology, Faculty of Medicine, Ege University, Izmir 35040, Turkey., Moon MH; Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 03722, Republic of Korea.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 19; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 19.
DOI: 10.3390/ijms241814264
Abstrakt: A comprehensive lipid profile was analyzed in patients with non-small cell lung cancer (NSCLC) using nanoflow ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. This study investigated 297 and 202 lipids in saliva and plasma samples, respectively, comparing NSCLC patients to healthy controls. Lipids with significant changes (>2-fold, p < 0.05) were further analyzed in each sample type. Both saliva and plasma exhibited similar lipid alteration patterns in NSCLC, but saliva showed more pronounced changes. Total triglycerides (TGs) increased (>2-3-fold) in plasma and saliva samples. Three specific TGs (50:2, 52:5, and 54:6) were significantly increased in NSCLC for both sample types. A common ceramide species (d18:1/24:0) and phosphatidylinositol 38:4 decreased in both plasma and saliva by approximately two-fold. Phosphatidylserine 36:1 was selectively detected in saliva and showed a subsequent decrease, making it a potential biomarker for predicting lung cancer. We identified 27 salivary and 10 plasma lipids as candidate markers for NSCLC through statistical evaluations. Moreover, this study highlights the potential of saliva in understanding changes in lipid metabolism associated with NSCLC.
Databáze: MEDLINE
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