Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model.

Autor: Jones GC; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Small CA; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Otteson DZ; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Hafen CW; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Breinholt JT; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Flora PD; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Burris MD; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Sant DW; Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Ruchti TR; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Yorgason JT; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA., Steffensen SC; Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.; Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Bills KB; Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 15; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 15.
DOI: 10.3390/ijms241814147
Abstrakt: Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have previously shown that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal and behavioral effects of chronic ethanol exposure. In this study, we employ a similar paradigm to assess the efficacy of WBV as a preventative measure of neuronal and behavioral effects of morphine withdrawal in a Wistar rat model. We demonstrate that concurrent administration of WBV at 80 Hz with morphine over a 5-day period significantly reduced adaptations in VTA GABA neuronal activity and NAc DA release and modulated expression of δ-opioid receptors (DORs) on NAc cholinergic interneurons (CINs) during withdrawal. We also observed a reduction in behavior typically associated with opioid withdrawal. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD) and should be examined translationally in humans.
Databáze: MEDLINE
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