Oxalate (dys)Metabolism: Person-to-Person Variability, Kidney and Cardiometabolic Toxicity.

Autor:	Baltazar P; Centro Hospitalar Universitário de Lisboa Central, E.P.E, 1150-199 Lisboa, Portugal.; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., de Melo Junior AF; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Fonseca NM; Centro Hospitalar Universitário de Lisboa Central, E.P.E, 1150-199 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Lança MB; Centro Hospitalar Universitário de Lisboa Central, E.P.E, 1150-199 Lisboa, Portugal., Faria A; CHRC, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal., Sequeira CO; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal., Teixeira-Santos L; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Monteiro EC; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Campos Pinheiro L; Centro Hospitalar Universitário de Lisboa Central, E.P.E, 1150-199 Lisboa, Portugal.; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Calado J; Centro Hospitalar Universitário de Lisboa Central, E.P.E, 1150-199 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal.; ToxOmics, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal., Sousa C; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal., Morello J; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal., Pereira SA; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Centro Clínico Académico de Lisboa, 1159-056 Lisboa, Portugal.
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2023 Aug 29; Vol. 14 (9). Date of Electronic Publication: 2023 Aug 29.
DOI:	10.3390/genes14091719
Abstrakt:	Oxalate is a metabolic end-product whose systemic concentrations are highly variable among individuals. Genetic (primary hyperoxaluria) and non-genetic (e.g., diet, microbiota, renal and metabolic disease) reasons underlie elevated plasma concentrations and tissue accumulation of oxalate, which is toxic to the body. A classic example is the triad of primary hyperoxaluria, nephrolithiasis, and kidney injury. Lessons learned from this example suggest further investigation of other putative factors associated with oxalate dysmetabolism, namely the identification of precursors (glyoxylate, aromatic amino acids, glyoxal and vitamin C), the regulation of the endogenous pathways that produce oxalate, or the microbiota's contribution to oxalate systemic availability. The association between secondary nephrolithiasis and cardiovascular and metabolic diseases (hypertension, type 2 diabetes, and obesity) inspired the authors to perform this comprehensive review about oxalate dysmetabolism and its relation to cardiometabolic toxicity. This perspective may offer something substantial that helps advance understanding of effective management and draws attention to the novel class of treatments available in clinical practice.
Databáze:	MEDLINE
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