| Autor: |
Anastasescu CM; Hospital of Neuropsychiatry Craiova, Children Mental Health Center, Pharmacology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Gheorman V; Department of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Popescu F; Pharmacology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Stoicănescu EC; Pediatry Department, Emergency Clinical Hospital Râmnicu Vâlcea, 200300 Râmnicu Vâlcea, Romania., Gheorman V; Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Riza AL; Human Genomics Laboratory, University of Medicine and Pharmacy, 050474 Craiova, Romania., Badea O; Department of Modern Languages, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Streață I; Human Genomics Laboratory, University of Medicine and Pharmacy, 050474 Craiova, Romania., Militaru F; Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Udriștoiu I; Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. |
| Abstrakt: |
The objective of this study was to analyze the serum amino acid profile in children diagnosed with autistic spectrum disorder (ASD) in southern Romania. The analysis aimed to provide insights into the underlying metabolic dysregulations associated with ASD. ASD is a neurodevelopmental disorder characterized by impaired social interaction, communication deficits, and restricted repetitive behaviors. Although the exact cause of ASD is largely unknown, recent evidence suggests that abnormalities in amino acid metabolism may contribute to its pathogenesis. Therefore, studying the amino acid profile in children with ASD could offer valuable information for understanding the metabolic disturbances associated with this complex disorder. This single-center study examined serum samples from children diagnosed with ASD, utilizing advanced analytical techniques to quantify the levels of different amino acids, amino acid derivatives, and amino acid-like substances. The results showed a lower level of taurine and a higher level of asparagine and leucine in the ASD group versus the control group. In the ASD group, we observed significant differences in tryptophan and alpha-aminobutyric acid levels based on age, with higher tryptophan levels in children older than 7 years when compared to children younger than 7 years; however, no significant correlations were found with the ASD group older than 7 years old. Additionally, younger children with ASD exhibited higher levels of alpha-aminobutyric acid than older children with ASD. The findings from this study contribute to the growing body of knowledge on the metabolic aspects of ASD, highlighting potential biomarkers and therapeutic targets for improving the management and treatment of ASD in children. |
