| Autor: |
Pantazi AC; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania., Kassim MAK; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania., Nori W; College of Medicine, Mustansiriyah University, Baghdad 10052, Iraq., Tuta LA; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Mihai CM; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Chisnoiu T; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Balasa AL; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Mihai L; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Lupu A; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Frecus CE; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania.; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Lupu VV; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Chirila SI; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania., Badescu AG; Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Hangan LT; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania., Cambrea SC; Faculty of Medicine, 'Ovidius' University of Constanta, 900470 Constanta, Romania. |
| Abstrakt: |
The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage kidney disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made and lay in three aspects: diagnostic, predictive, and therapeutic interventions. While these interventions show promising results in reducing uremic toxins and inflammation, challenges remain in the form of patient-specific GM variability, potential side effects, and safety concerns. Our understanding of GMs role in kidney disease is still evolving, necessitating further research to elucidate the causal relationship and mechanistic interactions. Personalized interventions focusing on specific GM signatures could enhance patient outcomes. However, comprehensive clinical trials are needed to validate these approaches' safety, efficacy, and feasibility. |
