Insights into Melanoma Clinical Practice: A Perspective for Future Research.

Autor: Lam GT; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Martini C; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Brooks T; Adelaide Medical School, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Aware Women's Health Private Clinic, Adelaide, SA 5006, Australia., Prabhakaran S; College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia., Hopkins AM; College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia., Ung BS; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Tang J; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Caruso MC; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Brooks RD; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Johnson IRD; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Sorvina A; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Hickey SM; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Karageorgos L; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia., Klebe S; College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.; Department of Surgical Pathology, SA Pathology at Flinders Medical Centre, Adelaide, SA 5042, Australia., O'Leary JJ; Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland., Brooks DA; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia.; Department of Histopathology, Trinity College Dublin, D02 PN40 Dublin, Ireland., Logan JM; Clinical and Health Sciences, University of South Australia, North Terrace, Adelaide, SA 5000, Australia.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Sep 19; Vol. 15 (18). Date of Electronic Publication: 2023 Sep 19.
DOI: 10.3390/cancers15184631
Abstrakt: Background: Early diagnosis is the key to improving outcomes for patients with melanoma, and this requires a standardized histological assessment approach. The objective of this survey was to understand the challenges faced by clinicians when assessing melanoma cases, and to provide a perspective for future studies.
Methods: Between April 2022 and February 2023, national and international dermatologists, pathologists, general practitioners, and laboratory managers were invited to participate in a six-question online survey. The data from the survey were assessed using descriptive statistics and qualitative responses.
Results: A total of 54 responses were received, with a 51.4% ( n = 28) full completion rate. Of the respondents, 96.4% reported ambiguity in their monthly melanoma diagnosis, and 82.1% routinely requested immunohistochemistry (IHC) testing to confirm diagnosis. SOX10 was the most frequently requested marker, and most respondents preferred multiple markers over a single marker. Diagnostic and prognostic tests, as well as therapeutic options and patient management, were all identified as important areas for future research.
Conclusions: The respondents indicated that the use of multiple IHC markers is essential to facilitate diagnostic accuracy in melanoma assessment. Survey responses indicate there is an urgent need to develop new biomarkers for clinical decision making at multiple critical intervention points.
Databáze: MEDLINE
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