Relation of MRI-Visible Perivascular Spaces and Other MRI Markers of Cerebral Small Vessel Disease.

Autor: Rodriguez Lara F; Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Toro AR; Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Pinheiro A; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA., Demissie S; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA., Ekenze O; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA.; Graduate Medical Sciences, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Martinez O; Department of Neurology, University of California Davis, Davis, CA 95817, USA., Parva P; Department of Radiology, Veterans Affairs Boston Healthcare System, Boston, MA 02118, USA.; Department of Radiology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Charidimou A; Department of Neurology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Ghosh S; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA.; Department of Neurology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., DeCarli C; Department of Neurology, University of California Davis, Davis, CA 95817, USA., Seshadri S; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA.; Department of Neurology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA., Habes M; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA., Maillard P; Department of Neurology, University of California Davis, Davis, CA 95817, USA., Romero JR; Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA.; Department of Neurology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2023 Sep 14; Vol. 13 (9). Date of Electronic Publication: 2023 Sep 14.
DOI: 10.3390/brainsci13091323
Abstrakt: Perivascular spaces (PVS) visible on brain MRI signal cerebral small vessel disease (CSVD). The coexistence of PVS with other CSVD manifestations likely increases the risk of adverse neurological outcomes. We related PVS to other CSVD manifestations and brain volumes that are markers of vascular brain injury and neurodegeneration. Framingham Heart Study (FHS) participants with CSVD ratings on brain MRI were included. PVS were rated in the basal ganglia (BG) and centrum semiovale (CSO) into grades I-IV and a category reflecting high burden in single or mixed CSO-BG regions. We related PVS to covert brain infarcts (CBI), white matter hyperintensities (WMH), cerebral microbleeds (CMB), total brain, hippocampal, and cortical gray matter volumes using adjusted multivariable regression analyses. In 2454 participants (mean age 54 ± 12 years), we observed that higher PVS burden in both BG and CSO was related to CMB in lobar and deep brain regions and increased WMH. Greater CSO PVS burden was associated with decreased total cortical gray volumes. PVS are associated with ischemic markers of CSVD and neurodegeneration markers. Further studies should elucidate the causality between PVS and other CSVD manifestations.
Databáze: MEDLINE
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