Use of ketogenic dietary therapy for drug-resistant epilepsy in early infancy.

Autor: Armeno M; Hospital de Pediatría Prof. Dr. J.P Garrahan, Buenos Aires, Argentina., Calligaris S; Hospital de Pediatría Prof. Dr. J.P Garrahan, Buenos Aires, Argentina., Gagiulo D; Hospital de Pediatría Prof. Dr. J.P Garrahan, Buenos Aires, Argentina., Cresta A; Hospital de Pediatría Prof. Dr. J.P Garrahan, Buenos Aires, Argentina., Vaccarezza MM; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Diez CG; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Alberti MJ; Hospital Sor Maria Ludovica, La Plata, Argentina., Viollaz R; Hospital Sor Maria Ludovica, La Plata, Argentina., Vilavedra F; Hospital Sor Maria Ludovica, La Plata, Argentina., Caraballo RH; Hospital de Pediatría Prof. Dr. J.P Garrahan, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Epilepsia open [Epilepsia Open] 2024 Feb; Vol. 9 (1), pp. 138-149. Date of Electronic Publication: 2023 Nov 20.
DOI: 10.1002/epi4.12836
Abstrakt: Objective: There is growing evidence that ketogenic dietary therapy (KDT) can be safely and efficiently used in young children, but little evidence exists on its use in newborns. Developmental and epileptic encephalopathies starting in the neonatal period or early infancy usually present a poor prognosis. The aim of this study was to evaluate effectiveness, safety, and survival of infants younger than 3 months of age with drug-resistant epilepsy in whom KDT was used.
Methods: A retrospective study was conducted to evaluate neonates and infants younger than 3 months who started KDT for drug-resistant developmental and epileptic encephalopathies at three referral centers. Data were collected on demographic features, time of epilepsy onset, epilepsy syndrome, seizure type, seizure frequency at diet onset, etiology, details regarding diet initiation, type of ketogenic formula, breastfeeding, route of administration, blood ketones, growth, length of NICU stay, and survival.
Results: Nineteen infants younger than 12 weeks of life who received KDT with a minimum follow-up of 1 month were included; 13 had early-infantile developmental and epileptic encephalopathy, four epilepsy of infancy with migrating focal seizures, and two focal epilepsy. A >50% response was observed in 73.7% at 1 month on the diet; 37% achieved a > 75% seizure reduction, and 10.5% became seizure free. At 3 months, a >50% decrease in seizure frequency was observed in 72.2%; 15.8% had a >75% reduction; 21% became seizure free. Overall survival was 76% at 1 year on diet. Incidence of acute and late adverse effects was low and most adverse effects were asymptomatic and manageable.
Significance: Our experience suggests that KDT is safe and effective in newborns and very young infants; however, further studies on the management of the diet in this vulnerable age group are necessary.
(© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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