Hypersensitive C-reactive protein as a potential indicator for predicting left ventricular hypertrophy in elderly community-dwelling patients with hypertension.

Autor: Song W; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Zhang C; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China., Tang J; Department of Ultrasound, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China., Li Y; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Jiao T; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China., Lin X; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China., Wang Y; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China., Fang J; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Sha J; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Ding T; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Cheng J; Department of General Practice, Jinyang Community Health Service Center, Shanghai, 200136, China., Li J; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. ljm13303818674@126.com.; Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai, 200120, China. ljm13303818674@126.com.
Jazyk: angličtina
Zdroj: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2023 Sep 27; Vol. 23 (1), pp. 480. Date of Electronic Publication: 2023 Sep 27.
DOI: 10.1186/s12872-023-03509-z
Abstrakt: Background: The aim of this study was to investigate the relationship between Hypersensitive C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) in elderly community-dwelling patients with hypertension.
Methods: A cross-sectional study was conducted, involving the recruitment of 365 elderly hypertensive residents ≥ 65 years of age from five communities. The participants were divided into two groups: an LVH group (n = 134) and a non-LVH group (n = 231), based on the left ventricular mass index (LVMI) determined by echocardiography. Spearman correlation analysis was used to assess the relationship between hs-CRP and LVH. Univariate and Multivariate analysis was performed to detect variables associated with LVH. The diagnostic value of hs-CRP for LVH was expressed as the area under the receiver operating characteristic (ROC) curve.
Results: The incidence of LVH in elderly hypertension patients in the community was 36.7%. The hs-CRP levels were significantly higher in subjects with LVH compared to those without LVH (1.9 [0.8, 2.9] vs. 0.7 [0.4, 1.4], P = 0.002). Spearman correlation analysis demonstrated a positive correlation between hs-CRP and LVMI (r = 0.246, P < 0.001), as well as with IVST (r = 0.225, P < 0.001) and LVPWT (r = 0.172, P = 0.001). Among elderly hypertensive residents in the community, the cut-off value of hs-CRP for diagnosing LVH was 1.25 mg/L (sensitivity: 57.5%; specificity: 78.4%), and the area under the ROC curve for hs-CRP to predict LVH was 0.710 (95%CI: 0.654-0.766; P < 0.001). In the final model, hs-CRP ≥ 1.25 mg/L (OR = 3.569; 95%CI, 2.153-5.916; P<0.001) emerged as an independent risk factor for LVH. This association remained significant even after adjusting for various confounding factors (adjusted OR = 3.964; 95%CI, 2.323-6.765; P < 0.001).
Conclusions: This community-based cohort of elderly hypertensive individuals demonstrates a strong association between hs-CRP levels and the presence of LVH. The hs-CRP ≥ 1.25 mg/L may serve as an independent predictor for LVH in hypertensive subjects and exhibit good diagnostic efficacy for LVH.
(© 2023. The Author(s).)
Databáze: MEDLINE
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