Cardiometabolic health in adults born with very low birth weight-a sibling study.

Autor: Kaseva N; Finnish Institute for Health and Welfare, Helsinki, Finland. nina.kaseva@fimnet.fi., Kuula J; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Radiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Sandboge S; Finnish Institute for Health and Welfare, Helsinki, Finland.; Psychology/Welfare Sciences, Faculty of Social Sciences, University of Tampere, Tampere, Finland., Hauta-Alus H; Finnish Institute for Health and Welfare, Helsinki, Finland.; Children's Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Research Program for Clinical and Molecular Metabolism (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland., Björkqvist J; Finnish Institute for Health and Welfare, Helsinki, Finland., Hovi P; Finnish Institute for Health and Welfare, Helsinki, Finland.; Children's Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Obstetrics and Gynecology and Human Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Vihervaara T; Finnish Institute for Health and Welfare, Helsinki, Finland., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Obesity Center, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kajantie E; Finnish Institute for Health and Welfare, Helsinki, Finland.; Children's Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 Jan; Vol. 95 (1), pp. 316-324. Date of Electronic Publication: 2023 Sep 27.
DOI: 10.1038/s41390-023-02828-3
Abstrakt: Background: Preterm survivors have increased risk for impaired cardiometabolic health. We assessed glucose regulation and cardiometabolic biomarkers in adult very low birth weight (VLBW, <1500 g) survivors, using siblings as controls.
Methods: VLBW-participants were matched with term-born, same-sex siblings. At mean age 29.2 years (SD 3.9), 74 VLBW-adults and 70 siblings underwent a 2-h 75 g oral glucose tolerance test and blood tests for assessment of cardiometabolic biomarkers.
Results: Of participants, 23 (31%) VLBW and 11 (16%) sibling-controls met World Health Organization criteria for impaired glucose regulation (OR adjusted for age and sex 2.5, 95% CI: 1.1 to 5.8). Adjusting for age and sex, VLBW-participants showed 9.2% higher 2-h glucose (95% CI: 0.4% to 18.8%) than their siblings. Also, fasting (13.4%, -0.3% to 29.0%) and 2-h free fatty acids (15.6%, -2.4% to 36.9%) were higher in VLBW-participants. These differences were statistically significant only after further adjusting for confounders. No statistically significant differences were found regarding other measured biomarkers, including insulin resistance, atherogenic lipid profiles or liver tests.
Conclusions: VLBW-adults showed more impaired fatty acid metabolism and glucose regulation. Differences in cardiometabolic biomarkers were smaller than in previous non-sibling studies. This may partly be explained by shared familial, genetic, or environmental factors.
Impact: At young adult age, odds for impaired glucose regulation were 3.4-fold in those born at very low birth weight, compared to same-sex term-born siblings. Taking into consideration possible unmeasured, shared familial confounders, we compared cardiometabolic markers in adults born preterm at very low birth weight with term-born siblings. Prematurity increased risk for impaired glucose regulation, unrelated to current participant characteristics, including body mass index. In contrast to previous studies, differences in insulin resistance were not apparent, suggesting that insulin resistance may partially be explained by factors shared between siblings. Also, common cardiometabolic biomarkers were similar within sibling pairs.
(© 2023. The Author(s).)
Databáze: MEDLINE
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