Which clinical factors and biochemical parameters are associated with late-life major depression?

Autor: Buoli M; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Legnani F; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Nosari G; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Pan A; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Ciappolino V; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Esposito CM; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Ceresa A; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Di Paolo M; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Surace T; Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, Monza, Italy., Auxilia AM; Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy., Capellazzi M; Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy., Tagliabue I; Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy., Cirella L; Healthcare Professionals Department, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Zanelli Quarantini F; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Dakanalis A; Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy., Clerici M; Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, Monza, Italy.; Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy., Capuzzi E; Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, Monza, Italy., Caldiroli A; Psychiatric Department, Azienda Socio Sanitaria Territoriale Monza, Monza, Italy.
Jazyk: angličtina
Zdroj: International journal of psychiatry in clinical practice [Int J Psychiatry Clin Pract] 2023 Nov; Vol. 27 (4), pp. 359-366. Date of Electronic Publication: 2023 Nov 07.
DOI: 10.1080/13651501.2023.2260426
Abstrakt: Introduction: Late-life major depression (MD) is a frequent and high-cost psychiatric disorder. Our purpose was to detect clinical and biological factors possibly associated with this condition to better prevent and treat it.
Methods: We recruited 343 patients, consecutively admitted for a Major Depressive Episode to the inpatient clinic of Policlinico of Milan and ASST Monza, Italy. A large set of clinical and biochemical variables was collected from clinical charts. Univariate analyses were performed both dividing the sample into two groups (age < or ≥65) and considering age as a continuous quantitative variable. Regression analyses were then performed considering as independent variables only those statistically significant at univariate analyses.
Results: Patients aged ≥ 65 resulted in having longer duration of illness, shorter duration of last antidepressant therapy, higher number of antidepressants assumed in the past, higher frequency of treatment-resistant depression, higher frequency of overweight/obesity and diabetes. As for biochemical parameters, patients ≥ 65 showed lower total plasmatic proteins and albumin, higher uric acid and creatinine.
Conclusions: These preliminary results suggest less effectiveness of antidepressants, more susceptibility to metabolic disorders and poor nutritional status in patients with late-life depression; such aspects may consequently be taken into consideration for a proper therapeutic approach. KEY POINTSDepression in late life seems to be associated with poorer response to antidepressants;Clinicians should prefer compounds with minimal pharmacokinetic interactions and less risk of side effects including metabolic ones;The poor nutritional status and the higher risk of metabolic disorders in older patients points out the importance of proper diet and healthy lifestyle in this group of subjects;Further studies are needed to confirm the results of this research.
Databáze: MEDLINE
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