Dysregulation of Cholesterol Homeostasis in Ovarian Cancer.

Autor: Qusairy Z; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Gangloff A; CHU de Québec-Université Laval Research Center, Québec City, QC G1V 4G2, Canada.; Faculty of Medicine, Laval University, Québec City, QC G1V 0A6, Canada., Leung SOA; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada.
Jazyk: angličtina
Zdroj: Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Sep 13; Vol. 30 (9), pp. 8386-8400. Date of Electronic Publication: 2023 Sep 13.
DOI: 10.3390/curroncol30090609
Abstrakt: Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer.
Databáze: MEDLINE
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