Agarose Cryogels: Production Process Modeling and Structural Characterization.

Autor:	Mancino R; Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.; Eng4Life Srl, Via Circumvallazione 39, 83100 Avellino, AV, Italy., Caccavo D; Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.; Eng4Life Srl, Via Circumvallazione 39, 83100 Avellino, AV, Italy.; EST Srl, Academic Spin-Off, Via Circumvallazione 39, 83100 Avellino, AV, Italy., Barba AA; Eng4Life Srl, Via Circumvallazione 39, 83100 Avellino, AV, Italy.; EST Srl, Academic Spin-Off, Via Circumvallazione 39, 83100 Avellino, AV, Italy.; Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy., Lamberti G; Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.; Eng4Life Srl, Via Circumvallazione 39, 83100 Avellino, AV, Italy.; EST Srl, Academic Spin-Off, Via Circumvallazione 39, 83100 Avellino, AV, Italy., Biasin A; Department of Engineering and Architecture, University of Trieste, Via Valerio 6, 34127 Trieste, TS, Italy., Cortesi A; Department of Engineering and Architecture, University of Trieste, Via Valerio 6, 34127 Trieste, TS, Italy., Grassi G; Department of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, 34149 Trieste, TS, Italy., Grassi M; Department of Engineering and Architecture, University of Trieste, Via Valerio 6, 34127 Trieste, TS, Italy., Abrami M; Department of Engineering and Architecture, University of Trieste, Via Valerio 6, 34127 Trieste, TS, Italy.
Jazyk:	angličtina
Zdroj:	Gels (Basel, Switzerland) [Gels] 2023 Sep 20; Vol. 9 (9). Date of Electronic Publication: 2023 Sep 20.
DOI:	10.3390/gels9090765
Abstrakt:	A cryogel is a cross-linked polymer network with different properties that are determined by its manufacturing technique. The formation of a cryogel occurs at low temperatures and results in a porous structure whose pore size is affected by thermal conditions. The adjustable pore sizes of cryogels make them attractive for diverse applications. In this study, the influence of the external operational temperature, which affects the cooling and freezing rates, on the production of cryogels with 2% w / w agarose is investigated. Moreover, a mathematical model is developed to simulate the cryogel production process and provide an initial estimate of the pore size within the structure. The predictions of the model, supported by qualitative light microscopy images, demonstrate that cryogels produced at higher process temperatures exhibit larger pore sizes. Moreover, the existence of pore size distribution within the gel structure is confirmed. Finally, stress relaxation tests, coupled with an image analysis, validates that cryogels produced at lower temperatures possess a higher stiffness and slower water release rates.
Databáze:	MEDLINE
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