Development of biomass waste-based carbon quantum dots and their potential application as non-toxic bioimaging agents.

Autor:	Abu N; Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus Kubang Kerian 16150 Kelantan Malaysia nhidayah@sirim.my.; Advanced Materials Research Centre (AMREC), SIRIM Berhad Lot 34, Jalan Hi-Tech 2/3, Kulim, Hi-Tech Park 09000 Kulim Malaysia., Chinnathambi S; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University Kyoto Japan chinnathambi.shanmugavel.8s@kyoto-u.ac.jp namasivayam.ganeshpandian.5z@kyoto-u.ac.jp., Kumar M; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University Kyoto Japan chinnathambi.shanmugavel.8s@kyoto-u.ac.jp namasivayam.ganeshpandian.5z@kyoto-u.ac.jp., Etezadi F; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University Kyoto Japan chinnathambi.shanmugavel.8s@kyoto-u.ac.jp namasivayam.ganeshpandian.5z@kyoto-u.ac.jp., Bakhori NM; Advanced Materials Research Centre (AMREC), SIRIM Berhad Lot 34, Jalan Hi-Tech 2/3, Kulim, Hi-Tech Park 09000 Kulim Malaysia., Zubir ZA; Advanced Materials Research Centre (AMREC), SIRIM Berhad Lot 34, Jalan Hi-Tech 2/3, Kulim, Hi-Tech Park 09000 Kulim Malaysia., Md Salleh SN; Advanced Materials Research Centre (AMREC), SIRIM Berhad Lot 34, Jalan Hi-Tech 2/3, Kulim, Hi-Tech Park 09000 Kulim Malaysia., Shueb RH; Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus Kubang Kerian 16150 Kelantan Malaysia nhidayah@sirim.my., Karthikeyan S; Centre for Healthcare Advancement, Innovation and Research, Vellore Institute of Technology Chennai 600 127 India., Thangavel V; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University Kyoto Japan chinnathambi.shanmugavel.8s@kyoto-u.ac.jp namasivayam.ganeshpandian.5z@kyoto-u.ac.jp., Abdullah J; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang Serdang 43400 Selangor Malaysia jafar@upm.edu.my., Pandian GN; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University Kyoto Japan chinnathambi.shanmugavel.8s@kyoto-u.ac.jp namasivayam.ganeshpandian.5z@kyoto-u.ac.jp.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Sep 25; Vol. 13 (40), pp. 28230-28249. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI:	10.1039/d3ra05840a
Abstrakt:	Over recent years, carbon quantum dots (CQDs) have advanced significantly and gained substantial attention for their numerous benefits. These benefits include their simple preparation, cost-effectiveness, small size, biocompatibility, bright luminescence, and low cytotoxicity. As a result, they hold great potential for various fields, including bioimaging. A fascinating aspect of synthesizing CQDs is that it can be accomplished by using biomass waste as the precursor. Furthermore, the synthesis approach allows for control over the physicochemical characteristics. This paper unequivocally examines the production of CQDs from biomass waste and their indispensable application in bioimaging. The synthesis process involves a simple one-pot hydrothermal method that utilizes biomass waste as a carbon source, eliminating the need for expensive and toxic reagents. The resulting CQDs exhibit tunable fluorescence and excellent biocompatibility, making them suitable for bioimaging applications. The successful application of biomass-derived CQDs has been demonstrated through biological evaluation studies in various cell lines, including HeLa, Cardiomyocyte, and iPS, as well as in medaka fish eggs and larvae. Using biomass waste as a precursor for CQDs synthesis provides an environmentally friendly and sustainable alternative to traditional methods. The resulting CQDs have potential applications in various fields, including bioimaging. Competing Interests: The authors declare no competing interests. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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