Prognostic performance of pretreatment systemic immune-inflammation index in women with epithelial ovarian cancer.

Autor:	Okunade KS; Department of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.; Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria.; Center for Clinical Trial, Research, & Implementation Science (CCTRIS), College of Medicine, University of Lagos, Lagos, Nigeria., John-Olabode SO; Department of Haematology & Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria., Soibi-Harry AP; Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria., Okoro AC; Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria., Adejimi AA; Department of Community Health & Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria., Ademuyiwa IY; Department of Nursing Science, College of Medicine, University of Lagos, Lagos, Nigeria., Osunwusi B; Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria., Adelabu H; Center for Clinical Trial, Research, & Implementation Science (CCTRIS), College of Medicine, University of Lagos, Lagos, Nigeria., Salako O; Department of Radiation Biology, Radiotherapy & Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2023 Aug 28; Vol. 9 (10), pp. FSO897. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023).
DOI:	10.2144/fsoa-2023-0108
Abstrakt:	Purpose: This study investigated the prognostic performance of the systemic immune-inflammation index (SII) in patients with epithelial ovarian cancer (EOC) in Lagos, Nigeria. Methods: We performed a secondary analysis of the data of 91 women who had treatment for EOC between 2009 and 2018. The associations between pretreatment SII and survivals were tested. Results: Pretreatment SII more than 610.2 was a significant independent predictor of reduced progression-free survival (HR = 2.68; 95% CI, 1.17 to 6.09) while SII greater than 649.0 was a significant independent predictor of reduced 3-year overall survival (HR = 2.01; 95% CI, 1.01 to 3.99). Conclusion: These findings suggest that high SII may be a potential prognostic indicator and useful marker for more intensive surveillance and design of personalized treatment in patients with EOC. Competing Interests: The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. (© 2023 The Authors.)
Databáze:	MEDLINE
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