Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID-19: A case-control study.

Autor: Shah S; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Paudel K; Nepal Health Frontiers Kathmandu Tokha Nepal.; Department of Allied Health Sciences University of Connecticut Mansfield Storrs Connecticut USA., Bhattarai A; Institute of Medicine Tribhuvan University Maharajgunj Nepal.; Medical Database Irvine California USA., Thapa S; Westchester Medical Center New York USA., Bhusal S; Nepal Health Frontiers Kathmandu Tokha Nepal.; Department of Allied Health Sciences University of Connecticut Mansfield Storrs Connecticut USA., Adhikari YR; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Adhikari TB; Nepal Health Frontiers Kathmandu Tokha Nepal.; Department of Public Health Aarhus University Aarhus C Denmark., Bhatta N; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Mandal P; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Sharma P; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Budha B; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Aryal S; Institute of Medicine Tribhuvan University Maharajgunj Nepal., Das SK; Department of Pulmonology and Critical Care, Institute of Medicine Tribhuvan University Maharajgunj Nepal., Pant P; Department of Pulmonology and Critical Care, Institute of Medicine Tribhuvan University Maharajgunj Nepal.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2023 Sep 25; Vol. 6 (9), pp. e1579. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI: 10.1002/hsr2.1579
Abstrakt: Background and Aims: The effectiveness of coronavirus disease 2019 (COVID-19) vaccines in reducing symptoms, disease advancement, complications, and mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been well-established. This case-control study aimed to compare different blood parameters, and prognostic and survival outcomes of COVID-19 patients based on vaccination status.
Methods: We performed a case-control study that included hospitalized patients with COVID-19 at Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Individuals who received vaccination were designated as cases and unvaccinated individuals as controls. Demographics, co-morbidity, clinical data, laboratory data, and disease outcomes were recorded for both groups. Multivariate, Cox, and linear regression were used for analysing blood parameters, hospital admission, survival, and hospital stay, respectively, between cases and controls.
Results: Out of 100 participants enrolled, 46 were vaccinated, and 54 weren't. At admission, ferritin and erythrocyte sedimentation rate (ESR) were significantly lower in cases. At discharge, cases showed a higher monocyte than controls. Ferritin, ESR, and d-imer showed excellent performance in determining the severity of symptoms. Significant correlation and regression of ferritin and ESR with the length of hospital stay was observed. Length of hospital stay was significantly lower in cases than in controls. No significant differences between cases and controls were observed in mortality.
Conclusion: COVID-19 vaccines effectively reduced hospitalization duration. Ferritin and ESR were significantly lower in vaccinated individuals and showed the best utility in monitoring the disease.
Competing Interests: The authors declare no conflict of interest to disclose.
(© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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