Use of biomarkers for predicting a malignant course in acute ischemic stroke: an observational case-control study.

Autor: Guimarães de Almeida Barros A; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil. xandebarros@gmail.com., Roquim E Silva L; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Pessoa A; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Eiras Falcão A; Medical School of Universidade Estadual de Campinas, R. Vital Brasil, 251, Cidade Universitária, Campinas, 13083-888, Brazil., Viana Magno LA; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Valadão Freitas Rosa D; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Aurelio Romano Silva M; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Marques de Miranda D; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil., Nicolato R; Medical School of Universidade Federal de Minas Gerais, Prof. Alfredo Balena Avenue, 190, Belo Horizonte, 30130-100, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Sep 26; Vol. 13 (1), pp. 16097. Date of Electronic Publication: 2023 Sep 26.
DOI: 10.1038/s41598-023-43408-z
Abstrakt: Acute ischemic stroke is a sudden neurological event caused by brain ischemia. Patients with large vessel occlusion are at high risk of developing significant cerebral edema, which can lead to rapid neurological decline. The optimal timing for decompressive hemicraniectomy to prevent further brain damage is still uncertain. This study aimed to identify potential predictors of severe brain edema. The data indicate that specific cytokines may help identify patients with a higher risk of developing life-threatening brain swelling in the early phase post-stroke. The association between a positive biomarker and the outcome was calculated, and three biomarkers-S100B protein, MMP-9, and IL-10-were found to be significantly associated with malignant edema. A model was derived for early predicting malignant cerebral edema, including S100B protein and IL-1 beta. These findings suggest that molecular biomarkers related to the ischemic cascade may be a helpful way of predicting the development of malignant cerebral edema in ischemic stroke patients, potentially widening the time window for intervention and assisting in decision-making. In conclusion, this study provides insights into the molecular mechanisms of severe brain edema and highlights the potential use of biomarkers in predicting the course of ischemic stroke.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje