Clinical outcomes of Staphylococcus capitis isolation from neonates, England, 2015-2021: a retrospective case-control study.

Autor:	Yuan JM; Field Service, UK Health Security Agency, London, UK JinMin.Yuan@ukhsa.gov.uk., Nugent C; UK Field Epidemiology Training Programme, UK Health Security Agency, Belfast, UK., Wilson A; Field Service, UK Health Security Agency, London, UK., Verlander NQ; Statistics Unit, Statistics, Modelling and Economics Department, UK Health Security Agency, London, UK., Alexander E; Field Service, UK Health Security Agency, London, UK., Fleming P; Homerton Healthcare NHS Foundation Trust, London, UK.; Queen Mary University of London, London, UK., Modi N; Section of Neonatal Medicine, Imperial College London, London, UK.; Chelsea and Westminster Healthcare NHS Trust, London, UK., Oughham K; Section of Neonatal Medicine, Imperial College London, London, UK., Ratnaraja N; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Wan Y; Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Use and Sepsis Division, UK Health Security Agency, London, UK.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, UK., Thorn L; Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Use and Sepsis Division, UK Health Security Agency, London, UK., Felgate H; Quadram Institute Bioscience, Norwich, UK., Webber MA; Quadram Institute Bioscience, Norwich, UK., Ogundipe E; Chelsea and Westminster Healthcare NHS Trust, London, UK.; Faculty of Medicine, Imperial College London, London, UK., Brown CS; Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Use and Sepsis Division, UK Health Security Agency, London, UK.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, UK., Paranthaman K; Field Service, UK Health Security Agency, London, UK., Demirjian A; Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Use and Sepsis Division, UK Health Security Agency, London, UK.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, UK.; Faculty of Medicine, Imperial College London, London, UK.; Department of Paediatric Infectious Diseases and Immunology, Evelina London Children's Hospital, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2024 Feb 19; Vol. 109 (2), pp. 128-134. Date of Electronic Publication: 2024 Feb 19.
DOI:	10.1136/archdischild-2023-325887
Abstrakt:	Objective: Staphylococcus capitis , a coagulase-negative staphylococci (CoNS) species, has been increasingly detected from UK sterile site samples and has caused neonatal unit outbreaks worldwide. We compared survival to discharge and 30-day mortality for the detection of S. capitis versus other CoNS species. Methods: In this retrospective case-control study, we included hospitalised infants with any CoNS species detected from a normally sterile body site up to 90 days of age. We linked English laboratory reports from the Second Generation Surveillance System database, mortality data from the Personal Demographics Service, and neonatal unit admissions from the National Neonatal Research Database. In primary analysis, multivariable logistic regression was used, with two co-primary outcomes: survival to discharge and death within 30 days of positive specimen date. Sensitivity analyses using multiply imputed datasets followed. Results: We identified 16 636 CoNS episodes relating to 13 745 infants. CoNS episodes were highest among infants born extremely preterm (22-27 weeks) and with extremely low birth weight (400-999 g). In primary analysis, there were no differences in survival to discharge (p=0.71) or 30-day mortality (p=0.77) between CoNS species. In sensitivity analyses, there were no differences in outcomes between infection with four of the most common CoNS species ( Staphylococcus epidermidis, S. capitis , Staphylococcus haemolyticus and Staphylococcus warneri ) but the remaining CoNS species were at higher risk of adverse outcomes when treated in aggregate. Conclusion: Infants with S. capitis detected from sterile site samples did not experience significant differences in either survival to discharge or 30-day mortality compared with infants with detection of other common CoNS species. Competing Interests: Competing interests: YW is an Imperial Institutional Strategic Support Fund Springboard Research Fellow, funded by the Wellcome Trust and Imperial College London. YW, AD and CSB are affiliated with the National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London in partnership with the UK Health Security Agency (formerly Public Health England), in collaboration with Imperial Healthcare Partners, University of Cambridge and University of Warwick. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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