The association between preconception cannabis use and gestational diabetes mellitus: The Preconception Period Analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium.

Autor: Pan K; Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Jukic AM; Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA., Mishra GD; School of Public Health, University of Queensland, Herston, Queensland, Australia., Mumford SL; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wise LA; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA., Schisterman EF; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ley SH; Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Charlton BM; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Chavarro JE; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Hart JE; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Xiong X; Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Barbosa-Leiker C; College of Nursing, Washington State University, Spokane, Washington, USA., Schliep KC; Division of Public Health, Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA., Shaffer JG; Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Bazzano LA; Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Harville EW; Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Jazyk: angličtina
Zdroj: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2024 Jan; Vol. 38 (1), pp. 69-85. Date of Electronic Publication: 2023 Sep 26.
DOI: 10.1111/ppe.13008
Abstrakt: Background: The metabolic changes that ultimately lead to gestational diabetes mellitus (GDM) likely begin before pregnancy. Cannabis use might increase the risk of GDM by increasing appetite or promoting fat deposition and adipogenesis.
Objectives: We aimed to assess the association between preconception cannabis use and GDM incidence.
Methods: We analysed individual-level data from eight prospective cohort studies. We identified the first, or index, pregnancy (lasting ≥20 weeks of gestation with GDM status) after cannabis use. In analyses of pooled individual-level data, we used logistic regression to estimate study-type-specific odds ratios (OR) and 95% confidence intervals (CI), adjusting for potential confounders using random effect meta-analysis to combine study-type-specific ORs and 95% CIs. Stratified analyses assessed potential effect modification by preconception tobacco use and pre-pregnancy body mass index (BMI).
Results: Of 17,880 participants with an index pregnancy, 1198 (6.7%) were diagnosed with GDM. Before the index pregnancy, 12.5% of participants used cannabis in the past year. Overall, there was no association between preconception cannabis use in the past year and GDM (OR 0.97, 95% CI 0.79, 1.18). Among participants who never used tobacco, however, those who used cannabis more than weekly had a higher risk of developing GDM than those who did not use cannabis in the past year (OR 2.65, 95% CI 1.15, 6.09). This association was not present among former or current tobacco users. Results were similar across all preconception BMI groups.
Conclusions: In this pooled analysis of preconception cohort studies, preconception cannabis use was associated with a higher risk of developing GDM among individuals who never used tobacco but not among individuals who formerly or currently used tobacco. Future studies with more detailed measurements are needed to investigate the influence of preconception cannabis use on pregnancy complications.
(© 2023 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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